endothelium in vascular disease has enabled the development of clinical tests to evaluate
the functional properties of normal and activated endothelium. 5 Ideally, such tests should be …

… In this review, we focus on new insights in the regulatory machinery of necroptosis. We further
discuss the role of necroptosis in different pathologies, its potential as a therapeutic target …

Introduction: Caveolae are specialized plasma membrane micro-invaginations of most
mammalian cell types. The organization and function of caveolae are carried out by their coat …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons resulting
in progressive paralysis and respiratory failure. About 1 in every 400 people dies of ALS, …

… We discuss how MMPs and tPA contribute to BBB disruption during ischemic stroke and
highlight recent findings of molecular signaling pathways involved in neurotoxicity of tPA therapy…

Estrogens play a crucial physiological function in the brain; however, debates exist
concerning the role of estrogens in Alzheimer’s disease (AD). Women during pre-, peri-, or …

… Molecules involved in osteosarcoma cell migration and invasion may be good therapeutic
targets. Wan et al. [14] reported that integrin β-4, which is highly expressed in osteosarcoma …

… Necroptosis is proposed to offer a novel therapeutic target for stroke with an extended … for
cancer therapy that potentiate available cytotoxic therapies. Therefore, molecular insights into …

Background Nonalcoholic steatohepatitis (NASH) has been the second most common cause
of liver transplantation in the United States. To date, NASH pathogenesis has not been fully …

… Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved
in disease pathogenesis and progression may potentially lead to new therapeutic targets. …