Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases

S Siebert, A Tsoukas, J Robertson, I McInnes - Pharmacological reviews, 2015 - ASPET
… application of anticytokine therapies for other inflammatory diseases, particularly within the
… across diseases. Finally, we report on the current state of trials for newer therapeutic targets, …

miRNAs as therapeutic targets in inflammatory disease

Q Lu, R Wu, M Zhao, A Garcia-Gomez… - Trends in pharmacological …, 2019 - cell.com
therapeutic targets in these diseases. In this review, by selecting several examples of
inflammatory diseases, … of certain miRNAs in these diseases, their targets, and the importance of …

Toll-like receptors: promising therapeutic targets for inflammatory diseases

A Achek, D Yesudhas, S Choi - Archives of pharmacal research, 2016 - Springer
diseases. In this review, we discuss the emerging role of TLRs in the pathogenesis of
inflammatory diseases and how targeting of TLRs offers a promising therapeutic strategy for the …

[PDF][PDF] Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

JP Pelletier, J Martel‐Pelletier… - Arthritis & Rheumatism …, 2001 - stem-art.com
… that have the potential to become therapeutic targets. These pathways can be modified to
effectively retard the progression of the disease. A number of such new agents, referred to as …

The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases

É Toussirot - … (Formerly Current Drug Targets-Inflammation & …, 2012 - ingentaconnect.com
inflammatory diseases such as chronic joint diseases, inflammatory bowel diseases and
demyelinating diseases … as a relevant therapeutic target in autoimmune driven diseases, and …

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

S Kumar, J Boehm, JC Lee - Nature reviews Drug discovery, 2003 - nature.com
… , along with other therapeutictherapeutic targets for rheumatoid arthritis. The availability
of p38 MAPK inhibitors such as SB-203580 has led to their widespread use in many different in …

Macrophage migration inhibitory factor: a therapeutic target across inflammatory diseases

AY Hoi, MN Iskander, EF Morand - … Drug Targets-Inflammation …, 2007 - ingentaconnect.com
… a severe systemic autoimmune disease and agedependent inflammatory damage to end …
which paralleled the upregulation of other key inflammatory cytokines and chemokines such as …

New therapeutic target in inflammatory disease: macrophage migration inhibitory factor

EF Morand - Internal medicine journal, 2005 - Wiley Online Library
inflammatory diseases rather than being disease-specific. This implies the need to identify
a therapeutic target which participates in the range of mechanisms operative in inflammation

TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

M Feldmann, RN Maini - Nature medicine, 2003 - nature.com
… of human autoimmune diseases, an interest I had acquired at WEHI. In these diseases, …
I started by analyzing thyroid diseases, and from this study in the early 1980s I realized that …

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases

MD Ferrer, C Busquets-Cortés, X Capó… - Current medicinal …, 2019 - ingentaconnect.com
… : Inflammation plays a crucial role in the development of many complex diseases and disorders
including autoimmune diseases, … Prostaglandins play a regulatory role in inflammation. …