… Protein kinases and phosphatases are likely targets for the development of therapeutic drugs
since they are involved in specific signaling pathways which regulate cell functions such as …

… of more than 50 protein kinase inhibitors with proven or potential therapeutic value %r …
tyrosine kinases as well as compounds that target difl'erent families of serine/threonine kinases …

… approaches to target the inhibition of protein kinase signaling. … of therapeutic protein kinase
inhibitors, particularly as anti… that favor binding interactions with the target protein kinase. …

… by which this family of serine/threonine protein kinases relays information from intracellular
stimuli to biological responses. Many proteins have been identified as PKC substrates both in …

… PINK1, LRRK2 and several PD gene products have been associated with mitogen-activated
protein (MAP) and protein kinase B (AKT) kinase signaling pathways. C-Jun N-terminal …

… The protein kinase C (PKC) family comprises a group of highly related protein kinases that
have … homology among protein kinases in general and among PKC isozymes in particular. …

… -ATPcompetitive inhibitors of MEK appear unlikely to encounter drug resistance in clinical
trials, further emphasizing the significance of this kinase as an effective therapeutic target [44]. …

… of growth for protein kinase-targeting therapeutics, followed by … protein kinase-targeting
therapeutic for cancer is the ability of an individual compound to interact with multiple targets …

… activated PKB isoforms enable cancer cells to evade apoptosis which can be reversed by
blockade at PKB thereby establishing PKB as a therapeutic target for the treatment of cancer. …

… proliferation, differentiation, and survival and has been pursued as a therapeutic target in
diabetes, neurological disorders, and inflammation. The regulation of GSK3 differs from many …