… new requirements for special targets and novel therapies. Understanding the pathogenetic
… therapeutic targets and approaches. In this review, both existing and emerging targets, …

… Rheumatoid arthritis (RA) is an autoimmune disease that … interesting novel therapeutic targets
in the field of rheumatology: … We also review the therapy potential of biologicals and small-…

… Of these, strategies that target RAGE and its associated signaling events in our … therapeutic
target for RA. However, there remains a significant unmet clinical need for new therapies as …

… Based on these findings, GM-CSF inhibition is an attractive therapeutic target for RA. In
animal models, administration of GM-CSF exacerbates arthritis in the collagen-induced arthritis (…

… are therefore attractive therapeutic targets in these conditions. Anticytokine therapy for …
Finally, we report on the current state of trials for newer therapeutic targets, focusing mainly …

… to identify current therapeutic targets for RA based on data from the literature and drug target
related … This article aims to identify current therapeutic targets for RA based on data from the …

… and improvement of current therapeutic modalities. This review describes therapies that are
approved… focusing on cytokines, although other therapeutic targets of interest are mentioned. …

RA is a chronic, debilitating disease in which articular inflammation and joint destruction are
accompanied by systemic manifestations including anaemia, fatigue and osteoporosis. IL-6 …

… factor (HIF), and their roles as unique therapeutic targets in the field of RA. Some of the
less developed but potential targets like nucleotide-binding and oligomerization domain-like …

… such as thyroiditis, diabetes and rheumatoid arthritis 1,2 , … rheumatoid arthritis. This is not
possible in thyroditis. The enticing possibility of converting ideas to possible therapeutic targets …