… -resistant) diabetes. Currently, these are referred to as type 1 and type 2 diabetes mellitus
(… There is too often a delay in advancing therapy when glycemic control is inadequate, with …

… in patients with type 2 diabetes 5. Adapted with permission from Riddle MC, Diabetes Care
… At that time, typically between 5 and 10 years after diagnosis, insulin therapy is needed in a …

… effective therapies to defined diabetes subtypes. The recent increase in identified polygenic
factors related to type 2 diabetes and our understanding of the pathogenesis of diabetes …

… This overview describes how basal and bolus insulin release in type 2 diabetes differs
from normal patterns of insulin release and discusses the indications for insulin therapy and …

A number of well-designed epidemiological studies have linked type 2 diabetes mellitus (T2DM)
with an increased risk of Alzheimer's disease (AD). Several mechanisms could help to …

Incretin-based drugs, such as glucagon-like peptide-1 receptor agonists and dipeptidyl
peptidase 4 inhibitors, are now routinely used to treat type 2 diabetes mellitus. These agents …

… We randomly assigned 2368 patients with both type 2 diabetes and … therapy or intensive
medical therapy alone and to undergo either insulin-sensitization or insulin-provision therapy. …

… long-term complications in type 2 diabetes (1–3). Over time, most patients with type 2 diabetes
experience progressive β-cell dysfunction and will require insulin therapy, either alone or …

… these hormones is evident in type 2 diabetes mellitus (T2DM)… of incretin-based therapy
and selected clinical trials of these … therapy with metformin, and 0.7% as add-on therapy to …

Background Adding insulin to oral therapy in type 2 diabetes mellitus is customary when
glycemic control is suboptimal, though evidence supporting specific insulin regimens is limited. …