Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats

L Hickey, Y Li, SJ Fyson, TC Watson… - Journal of …, 2014 - Soc Neuroscience
… influences on spinal nociception. Using optogenetic targeting… < 0.0001) changes in hindpaw
thermal withdrawal thresholds. … discrete, bidirectional influences on thermal nociception that …

Psychophysical demonstration of bidirectional pain modulation (sensitization and desensitization) by ascending or descending progressions of thermal stimulus …

CJ Vierck, JL Riley III, F Wong, CD King, AP Mauderli - Brain research, 2010 - Elsevier
… variation in sequencing of step changes in thermal stimulation that both increased and …
effect of nociceptive temperature reduction has previously been shown for cutaneous thermal

Onset hyperalgesia and offset analgesia: Transient increases or decreases of noxious thermal stimulus intensity robustly modulate subsequent perceived pain …

BJ Alter, MS Aung, IA Strigo, HL Fields - PLoS One, 2020 - journals.plos.org
changes. Overall, this study demonstrates that the perceptual effect of a noxious thermal
stimulus is influenced in a bidirectional … exert bidirectional control over nociceptive transmission, …

Nociceptor sensory neuron–immune interactions in pain and inflammation

FA Pinho-Ribeiro, WA Verri, IM Chiu - Trends in immunology, 2017 - cell.com
… , nociceptors are ideally positioned to be the first responders to pathogens and tissue injury.
While pain is critical to induce behavioral changes … this bidirectional neuroimmune crosstalk …

… /6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception

CD Bryant, D Bagdas, LR Goldberg… - Molecular …, 2019 - journals.sagepub.com
… similar bidirectional effects on both formalin-induced nociceptive … affecting nociception, Ryr1
variants could lead to a change in … rather than a change in nociceptive transmission could …

Dental pain induced by an ambient thermal differential: pathophysiological hypothesis

A Le Fur-Bonnabesse, C Bodéré, C Hélou… - Journal of pain …, 2017 - Taylor & Francis
… structure, mechanisms of dental nociception and the thermal pain are also provided. …
change at the DEJ by about half a second. Citation6 With extreme thermal stimuli, a bidirectional

Thermosensitive transient receptor potential (TRP) channel agonists and their role in mechanical, thermal and nociceptive sensations as assessed using animal …

AH Klein, M Trannyguen, CL Joe… - Chemosensory …, 2015 - Springer
… in nociception, temperature, or mechanical sensation. Within six of the subfamilies (TRPV,
TRPM, TRPC, TRPA, and TRPP), eight TRP channels exhibit sensitivity to changes in …

Nociception and autonomic nervous system

P Cortelli, G Giannini, V Favoni, S Cevoli… - Neurological …, 2013 - Springer
… system elicited by mechanical, thermal, or chemical stimuli … The RVM exerts a bidirectional
control on spinal nociceptive … system, namely the ability to detect salient changes and, possibly…

Endocannabinoids have opposing effects on behavioral responses to nociceptive and non-nociceptive stimuli

T Summers, B Hanten, W Peterson, B Burrell - Scientific reports, 2017 - nature.com
bidirectional effects on behavioral responses to nociceptive … for changes in response to
nociceptive and non-nociceptive … , with the latter being sensitive to noxious mechanical, thermal

Transient analgesia evoked by noxious stimulus offset

JD Grill, RC Coghill - Journal of neurophysiology, 2002 - journals.physiology.org
nociceptive mechanisms process information about both increases and decreases in noxious
stimulus intensities, then changes in … alterations in noxious thermal stimuli. Psychophysical …