Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition
… pose inside the EGFR protein. In conclusion, the potent EGFR inhibitory activity of compound
7 was … Our results of EGFR inhibitory activity agreed with the previous history of quinoline or …
7 was … Our results of EGFR inhibitory activity agreed with the previous history of quinoline or …
Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors
PC Lv, CF Zhou, J Chen, PG Liu, KR Wang… - Bioorganic & medicinal …, 2010 - Elsevier
… thiazolidinone derivatives. Biological evaluation indicated that some of the synthesized
compounds are potent inhibitors of EGFR … of the EGFR in complex with an inhibitor to explore the …
compounds are potent inhibitors of EGFR … of the EGFR in complex with an inhibitor to explore the …
[HTML][HTML] Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAFV600E
… The most effective derivative against the lung cancer (A549) cell line was compound III (Figure
1), with an IC 50 value of 0.72 µM and promising EGFR inhibitory activity at a …
1), with an IC 50 value of 0.72 µM and promising EGFR inhibitory activity at a …
[PDF][PDF] Design and synthesis of certain novel arylidene thiazolidinone derivatives as anticancer agents
… inhibitor selectivity. Finally a Hydrophobic pocket though not used by ATP but plays an
important role in inhibitor … 2-amino-benzothiazole core as EGFR inhibitors. Our strategy was …
important role in inhibitor … 2-amino-benzothiazole core as EGFR inhibitors. Our strategy was …
New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti …
WAA Fadaly, TH Zidan, NM Kahk… - … of Enzyme Inhibition …, 2023 - Taylor & Francis
… inhibitor was maintained in target compounds 18a–j (ii) thiazolidinone moiety of both EGFR
inhibitors … linker of the EGFR inhibitor (6) and pyrazole moiety of HER-2 inhibitor (8) was …
inhibitors … linker of the EGFR inhibitor (6) and pyrazole moiety of HER-2 inhibitor (8) was …
[HTML][HTML] Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAFV600E
… of thiazolidinone derivatives and assayed for inhibitory action against EGFR and HER-2
kinases. Some of the synthesized compounds displayed potent EGFR and HER-2 inhibitory …
kinases. Some of the synthesized compounds displayed potent EGFR and HER-2 inhibitory …
[HTML][HTML] Design, synthesis, crystal structures and biological evaluation of some 1, 3-thiazolidin-4-ones as dual CDK2/EGFR potent inhibitors with potential apoptotic …
… of thiazolidinone derivatives have been the subject of substantial research (Zhou et al., 2020,
Santos et al., 2018). The thiazolidinone derivatives … Also, thiazolidinone derivatives have …
Santos et al., 2018). The thiazolidinone derivatives … Also, thiazolidinone derivatives have …
Design, Synthesis, Anticancer Evaluation and Molecular Modeling Studies of New Thiazolidinone‐Benzoate Scaffold as EGFR Inhibitors, Cell Cycle Interruption and …
S Magdy Eldaly, D Salama Zakaria… - Chemistry & …, 2023 - Wiley Online Library
… This research detailed synthesis of three series of thiazolidinone derivatives based on 4-formylphenyl
benzoate 1 a and 4-formyl-2-methoxyphenyl benzoate 1 b as key precursors and …
benzoate 1 a and 4-formyl-2-methoxyphenyl benzoate 1 b as key precursors and …
… , synthesis and anticervical cancer activity of new benzofuran–pyrazol-hydrazono-thiazolidin-4-one hybrids as potential EGFR inhibitors and apoptosis inducing …
HAS Abbas, SS Abd El-Karim - Bioorganic chemistry, 2019 - Elsevier
… cycle arrest in addition to effective EGFR tyrosine kinase suppression of … derivatives in this
study was based on hybridization of benzofuran-pyrazole core with substituted thiazolidinone …
study was based on hybridization of benzofuran-pyrazole core with substituted thiazolidinone …
Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors
KM Qiu, HH Wang, LM Wang, Y Luo, XH Yang… - Bioorganic & medicinal …, 2012 - Elsevier
… that thiazolidinone derivatives (TD, Fig. 1) were potent … -thiazolinone derivatives that may
function as inhibitors of EGFR … And some of them displayed potent EGFR and HER-2 inhibitory …
function as inhibitors of EGFR … And some of them displayed potent EGFR and HER-2 inhibitory …
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