Correlation of 18F-FLT uptake with equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in gastrointestinal cancer
R Kameyama, Y Yamamoto, K Izuishi… - Nuclear medicine …, 2011 - journals.lww.com
… transporter-1 (ENT1) messenger ribonucleic acid (mRNA) expression (R=0.03; P=0.90). (b)
There was a correlation between FLT SUV and thymidine kinase-1 (TK1) mRNA expression, …
There was a correlation between FLT SUV and thymidine kinase-1 (TK1) mRNA expression, …
… 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) uptake by PET correlates with thymidine kinase 1 expression: static and kinetic analysis of 18F-FLT PET studies in lung …
JS Brockenbrough, T Souquet… - Journal of Nuclear …, 2011 - Soc Nuclear Med
… F-FLT) PET and the expression of the proliferation marker Ki-67, and the protein expression
and enzymatic activity of thymidine kinase-1 (… ) of 18 F-FLT PET images were performed in a …
and enzymatic activity of thymidine kinase-1 (… ) of 18 F-FLT PET images were performed in a …
Evaluation of 3′-deoxy-3′-[18F]-fluorothymidine (18F-FLT) kinetics correlated with thymidine kinase-1 expression and cell proliferation in newly diagnosed …
A Shinomiya, N Kawai, M Okada, K Miyake… - European journal of …, 2013 - Springer
… The present study investigated the relationship between the kinetic parameters of 18 F-FLT
in vivo and thymidine kinase-1 (TK-1) expression and cell proliferation rate in vitro, and blood…
in vivo and thymidine kinase-1 (TK-1) expression and cell proliferation rate in vitro, and blood…
[HTML][HTML] Applications of PET imaging with the proliferation marker [18F]-FLT
M Peck, HA Pollack, A Friesen, M Muzi… - The quarterly journal …, 2015 - ncbi.nlm.nih.gov
… (FLT) is a good substrate for cytosolic thymidine kinase (TK-1)… FLT, FMAU is a better substrate
for mitochondrial thymidine … ENT1 expression might not reflect accumulation of FLT in vivo …
for mitochondrial thymidine … ENT1 expression might not reflect accumulation of FLT in vivo …
FLT: measuring tumor cell proliferation in vivo with positron emission tomography and 3′-deoxy-3′-[18F] fluorothymidine
A Salskov, VS Tammisetti, J Grierson… - Seminars in nuclear …, 2007 - Elsevier
… FLT is accepted as a substrate by thymidine kinase 1 (TK-1), which phosphorylates it, thereby
trapping it in cells.44, 58, 59 FLT… , 83 In terms of radiation exposure, 18 F-FLT administered …
trapping it in cells.44, 58, 59 FLT… , 83 In terms of radiation exposure, 18 F-FLT administered …
Molecular PET and PET/CT imaging of tumour cell proliferation using F-18 fluoro-L-thymidine: a comprehensive evaluation
… FLT is phosphorylated by thymidine kinase 1 (TK 1 ) but not … in TK 1 protein levels, FLT
uptake, PCNA expression and ATP … The uptake of 3′-deoxy-3′-[18F]fluorothymidine into …
uptake, PCNA expression and ATP … The uptake of 3′-deoxy-3′-[18F]fluorothymidine into …
The role of 18F-FLT in cancer imaging: does it really reflect proliferation?
A Dimitrakopoulou-Strauss, LG Strauss - European journal of nuclear …, 2008 - Springer
… F-FLT is taken up by both passive diffusion and facilitated transport by Na + -dependent
carriers and is then phosphorylated by thymidine kinase 1 (TK 1 ) to 18 F-FLT-… (18F)FLT PET for …
carriers and is then phosphorylated by thymidine kinase 1 (TK 1 ) to 18 F-FLT-… (18F)FLT PET for …
[18F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
CC Zhang, Z Yan, W Li, K Kuszpit, CL Painter… - Clinical Cancer …, 2012 - AACR
… by thymidine kinase 1 (TK1), at which point it becomes trapped in the cells. As a pyrimidine
analog, FLT … Using TaqMan analysis, we determined the baseline mRNA expression of 7 …
analog, FLT … Using TaqMan analysis, we determined the baseline mRNA expression of 7 …
Limits of [18F]-FLT PET as a Biomarker of Proliferation in Oncology
ET McKinley, GD Ayers, RA Smith, SA Saleh, P Zhao… - PloS one, 2013 - journals.plos.org
… specificity of TK1 expression and the extent to which tumors utilize thymidine salvage for …
FLT is monophosphorylated in a reaction catalyzed by the cytosolic enzyme thymidine kinase 1 …
FLT is monophosphorylated in a reaction catalyzed by the cytosolic enzyme thymidine kinase 1 …
The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models
K Heinzmann, DJ Honess, DY Lewis, DM Smith… - EJNMMI research, 2016 - Springer
… between endogenous thymidine concentrations and [18F]FLT uptake in a … F]FLT is
phosphorylated, and consequently trapped in cells, by thymidine kinase 1 (TK1), whose expression …
phosphorylated, and consequently trapped in cells, by thymidine kinase 1 (TK1), whose expression …
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