Deletion of thymidine kinase activity from L cells resistant to bromodeoxyuridine

S Kit, DR Dubbs, LJ Piekarski, TC Hsu - Experimental cell research, 1963 - Elsevier
thymidine to nucleotide form. The thymidine kinase activity of enzyme preparations from
suspension … 9 to 17 X 10-5 @l of thymidine phosphorylated per ,ug DC4 in 10 min at 38” but the …

The role of thymidine kinase in cancer diseases

O Topolcan, L Holubec Jr - Expert opinion on medical diagnostics, 2008 - Taylor & Francis
… levels of thymidine kinase in a variety of neoplasias. Determination of thymidine kinase helps
to … Elevated levels of thymidine kinase must always be interpreted together with a detailed …

Regulation of human thymidine kinase during the cell cycle.

JL Sherley, TJ Kelly - Journal of Biological Chemistry, 1988 - ASBMB
… of the regulation of thymidine kinase activity in cycling HeLa … thymidine kinase (Sherley
and Kelly, 1988), we have demonstrated that changes in the levels of thymidine kinase activity

Human thymidine kinase 1. Regulation in normal and malignant cells

B Munch-Petersen, L Cloos, HK Jensen… - Advances in enzyme …, 1995 - Elsevier
… Others have demonstrated that thymidine kinase activity is also regulated by post-… of TKl
activity, at least in HL60 cells, where the fluctuation of thymidine kinase activity was related to the …

Thymidine kinase, DNA synthesis and cancer

S Kit - Molecular and cellular biochemistry, 1976 - Springer
activities of enzymes functioning in nucleotide synthesis. Especially striking is the increase
of thymidine kinase activity, … The thymidine kinase isozymes of vertebrate cells have been …

Regulation of thymidine kinase synthesis in human cells

LJ Bello - Experimental cell research, 1974 - Elsevier
Thymidine kinase activity in KB cells TdR kinase has been shown to undergo periodic
increases and decreases in activity coinciding approximately with the beginning and end of DNA …

Thymidine kinase activity and incorporation of thymidine into DNA in zinc-deficient tissue

AS Prasad, D Oberleas - The Journal of laboratory and clinical …, 1974 - translationalres.com
… model, on the activity of thymidine kinase (TK) , an enzyme regarded as being essential for
DNA synthesis and cell division. Our results indicate that the TK activity is adversely affected …

Thymidine kinase and cancer monitoring

S Aufderklamm, T Todenhöfer, G Gakis, S Kruck… - Cancer letters, 2012 - Elsevier
… and adult thymidine kinase [5]. … thymidine kinase in the cell: thymidine triphosphate (TTP),
the product of the further phosphorylation of thymidine, acts as an inhibitor to thymidine kinase

Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA

SK Kim, BJ Wold - Cell, 1985 - cell.com
… Anti-sense thymidine kinase (TK) RNA was expressed as part of a chimeric dihydrofolate …
In several cell lines expressing high levels of anti-sense TK RNA, thymidine kinase activity was …

End-product inhibition of thymidine kinase activity in normal and leukemic human leukocytes

E Bresnick, RJ Karjala - Cancer Research, 1964 - AACR
Thymidine kinase activity in sonicated soluble preparations obtained from normal and … of
the competitive type (with thymidine). The 'apparent' Kmfor thymidine and the Kt for TTP and d-…