In vivo transfer of the herpes simplex virus type-1 thymidine kinase (HSV-1 TK) gene, with
subsequent administration of antiviral drugs such as ganciclovir, has emerged as a promising …

… accuracy with which FLT uptake predicted the activity of cytosolic thymidine kinase-1 (TK 1
)… the cellular uptake as a percentage of radioactivity in the same volume of medium. Uptake …

… The cellular uptake of thymidine and its phosphorylation are coupled; consequently, the …
accumulation of phosphorylated thymidine analogues reflects the activity of thymidine kinase (25…

… The cellular uptake of thymidine was highly dependent on the viral TK (vTK) activity. The TK
+ strain showed the highest level of intracellular thymidine uptake, … showed little uptake. The …

… pathway enzymes (eg, ofhost thymidine kinase activity during repair of cell damage).
Therefore, it is unlikely that a quantita tion with a standardized uptake value is useful! for the deter …

… Thymidine uptake into the acid-soluble fraction of several hamster cell lines differing in
levels of thymidine kinase was examined. Uptake is correlated directly with the level of this …

… Attempts to detect thymidine kinase genes in … thymidine kinase genes proved unsuccessful.
To determine if the inability to incorporate thymidine was due to the lack of thymidine kinase, …

… The initial step in TdR metabolism is phosphorylation by thymidine kinase-1 (TK 1 ). In …
To examine how some tumor-specific variations in cell biology influence PET tracer uptake, …

… cellular density (1 × 10 5 cells) in cell cultures of KBALB and KBALB-STK cells. The cellular
uptake of each compound (10−13) in both cell … Minimal uptake of all four compounds (10−13) …

… Because the cellular uptake of sufficient amounts of 10 B is a prerequisite for a boron delivery
agent for neutron capture therapy, in vitro uptake and retention studies were performed as …