… Moreover, the enzyme thymidine kinase has been implicated in growth regulation since
elevated levels of the enzyme have been found in replicating cells [3], such as regenerating liver …

… -sr39TK enzyme activity in cell or tissue lysates by … cell lysate protein after a fixed incubation
time. The other method, called the 'cell-uptake assay', takes into account the natural uptake …

… thymidine kinase. They validated the activities of all three proteins encoded by the fusion gene
in cell … In conclusion, a comparison study of D- and L-isomers of [ 125 I]FIAU in cell uptake …

… This assay examines cell viability by measuring calcein-AM uptake and esterification,
which results in green fluorescence, and cell death by measuring uptake of ethidium bromide …

… FLT is believed to be phosphorylated by thymidine kinase 1 (TK 1 ), a cell cycle regulated
cytoplasmic isozyme, and might be retained as a phosphorylated form [6], [16], [29] but not …

A library of sixteen 2nd generation amino- and amido-substituted carboranyl pyrimidine
nucleoside analogs, designed as substrates and inhibitors of thymidine kinase 1 (TK1) for …

… trapped within the cytosol after being monophosphorylated by thymidine kinase-1 (TK1), a …
as measures of cellular proliferation, we need to understand the mechanism of FLT uptake in …

… , in part due to exciting preliminary studies in cell cultures, animal models and humans [4],
[5], [6], [7], [8]. To date, FLT uptake has been correlated with many of the most commonly used …

… an excellent substrate of thymidine kinase 1 and its … cellular uptake and metabolism of [ 3
H]N5-2OH was followed for up to 120 minutes, as described in Materials and Methods. Uptake …

… the activity of the enzyme thymidine kinase (ATP-thymidine 5’-… exogenously supplied TdR
to thymidine monophosphate, and … , rates of uptake of 3H-TdR and thymidine kinase activity in …