… Among all present gene therapy protocols, combination of administration of GCV and
transfection of thymidine kinase gene of Herpes simplex virus (HSV-TK) into tumor cells is perhaps …

… cellular kinases such as thymidine kinases TK1 and TK2. TK1 is up regulated in the S-phase
of the cell … , including in vitro cell uptake and in vivo biodistribution and tumor uptake will be …

… Human mitochondrial thymidine kinase (TK2) is a pyrimidine deoxynucleoside kinase (dNK)
that catalyzes the phosphorylation of pyrimidine deoxynucleosides to their corresponding …

… The cells possess an excess of thymidine kinase, and thymidine is phosphorylated as … of
thymidine uptake by mammalian cells and the fact that a change in the level of thymidine kinase …

… thymidine kinase genes in 9L gliosarcoma cells reduced cell … by thymidine kinase following
5-fluorouracil treatment. … the herpes simplex virus type-1 thymidine kinase (HSV-TK) enzyme (…

… In vitro cell uptake indicated that all three compounds are taken up selectively in … uptake
in RG2 cells. The results indicate that [ 18 F]FBrVAU and [ 18 F]FTMAU have better uptake …

… The synthesis of isotopically labeled dT and the demonstration of its incorporation into
DNA after cellular uptake and phosphorylation were landmark discoveries in cell biology, …

The purpose of the present study was to evaluate the effectiveness of a 3-carboranyl thymidine
analogue (3CTA), 3-[5-{2-(2,3-dihydroxyprop-1-yl)-o-carboran-1-yl}pentan-1-yl] thymidine…

… cellular cycle, but is much higher and permanently expressed in malignant growing cells.
Using a new cytofluorometric assay for thymidine kinase … necessary events (uptake into the cell, …

… to both cellular-type thymidine kinase (TK) and cellular-type thymidylate kinase (TMK),
but … -TMK catalyzed the phosphorylation of thymidine to form thymidine monophosphate (TMP), …