… (dTMP) pool in the cytosol is mainly regulated by thymidine kinase 1 (TK1) and 5’(3’)-…
kinases, including deoxycytidine kinase, thymidine kinase 2 and deoxyguanosine kinase, as it …

… enzymes thymidylate synthase (TS) and thymidine kinase 1 (TK1) was evaluated in …
Pretreatment with FdUrd strongly increased the cellular uptake and the DNA incorporation …

… were counted, and becausethoroughly confluent monolayers were used, background
cellular uptake was minimal. Cellular uptake could be further decreased by adding BUdR to the …

… immediately by liquid scintillation counting (total cell uptake) … thymidine uptake as deming
that almost all thymidine taken up by the cell onstrated by the plate signal and p34cdc2 kinase …

… Various steps of the pathway of thymidine through … 3H]-thymidine cellular uptake and
incorporation into DNA ; the cellular nucleotide pools; and the concentration of thymidine in ascites. …

… thymidine derivatives, thymidine kinase (… uptake of 99m Tc-labeled thymidine was seen
in the tumor. As was found for the biodistribution study in normal mice, there was a high uptake …

… high uptake of [ 125 I]FIAU and [ 18 F]FLT in the bacterial infection site. [ 18 F]FLT uptake in
… In conclusion, the bacterial tk activity was confirmed by the cellular uptake and imaging with …

… rise in the kinase level could be prevented by puromycin and actino… kinase activity was also
found to increase when cell growth … kinase of Chang liver cell cultures is subject to control by …

… of deoxycytidine kinase by dCTP (16). The sites of cellular entry of nucleosides may also
be targets for modulation of nucleoside drug activity. In animal cells, the cellular uptake of …

… To fully understand the biological mechanism of 18 F-FLT uptake in brain tumors, it is
essential to know whether increased 18 F-FLT uptake is mainly driven by cell proliferation …