Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs
DM Voeller, JL Grem, Y Pommier, K Paull… - Cancer chemotherapy …, 2000 - Springer
… the H630 colon cancer cell line and the CEM human leukemia cell line, and … Thymidine
kinase (TK) activity was measure by a radiolabelled in vitro assay using H630 colon cancer cell …
kinase (TK) activity was measure by a radiolabelled in vitro assay using H630 colon cancer cell …
Inhibition of thymidine kinase activity and deoxyribonucleic acid synthesis in L cells infected with the meningopneumonitis agent
HS Lin - Journal of Bacteriology, 1968 - Am Soc Microbiol
… to induce the synthesis of thymidine kinase in LM (TK-) cells which contain no thymidine kinase
in the uninfected state. It … Limited thymidine uptake in Escherichia coli due to an inducible …
in the uninfected state. It … Limited thymidine uptake in Escherichia coli due to an inducible …
Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2)
LI Wiebe, W Sun, A Zhou, J Yang… - Current …, 2012 - ingentaconnect.com
… phosphorylation by thymidine kinases (TK1, TK2), cell uptake and … (~1 mM) concentrations,
although the cellular uptake of [3H]FT in … thymidine kinase (TK2) (58 % of TdR) and cytosolic …
although the cellular uptake of [3H]FT in … thymidine kinase (TK2) (58 % of TdR) and cytosolic …
Alkyl-fluorinated thymidine derivatives for imaging cell proliferation: II. Synthesis and evaluation of N3-(2-[18F] fluoroethyl)-thymidine
J Toyohara, A Hayashi, A Gogami… - Nuclear medicine and …, 2006 - Elsevier
… : (a) they should be selectively phosphorylated by thymidine kinase 1 (TK1); (b) they should
… performed an in vitro cell uptake study with N 3 -(2-fluoroethyl)-[2-sd 14 C]thymidine ([ 14 C]…
… performed an in vitro cell uptake study with N 3 -(2-fluoroethyl)-[2-sd 14 C]thymidine ([ 14 C]…
Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression
… thymidine analogue as a probe for imaging the expression of herpes simplex virus type-1
thymidine kinase … The HSV1-TK activity was evaluated by an in vitro cell-uptake assay, in which …
thymidine kinase … The HSV1-TK activity was evaluated by an in vitro cell-uptake assay, in which …
Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine …
H Corban-Wilhelm, WE Hull, G Becker, U Bauder-Wüst… - Gene Therapy, 2002 - nature.com
… resonance (NMR) spectroscopy of cultured AT-1/CDglyTK cell suspensions in vitro. With this
technique it was possible to detect the uptake of 5-FC, its intracellular conversion to 5-FU, a …
technique it was possible to detect the uptake of 5-FC, its intracellular conversion to 5-FU, a …
Cell cycle related [3H]thymidine uptake and its significance for the incorporation into DNA
K Naito, S Skog, B Tribukait, L Andersson… - Cell …, 1987 - Wiley Online Library
… Cellular uptake of [3H]thymidine ([3H]TdR) and incorporation into DNA of Ehrlich ascites
tumour cells were studied in relation to the cell … is phosphorylated by thymidine kinases to mono-…
tumour cells were studied in relation to the cell … is phosphorylated by thymidine kinases to mono-…
Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission …
… significantly but thymidine kinase and ATP levels were unchanged. Whole-cell assays …
To determine the mechanism of whole-cell plasma membrane transport, cell uptake studies …
To determine the mechanism of whole-cell plasma membrane transport, cell uptake studies …
Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the “bystander effect”
CY Chen, YN Chang, P Ryan, M Linscott… - Human gene …, 1995 - liebertpub.com
… GCV, a nucleoside analog, becomes cytotoxic after being converted to its triphospborylated
form through phosphorylation by HSV thymidine kinase and host cellular kinases. The …
form through phosphorylation by HSV thymidine kinase and host cellular kinases. The …
Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy
… In order to compare the transfection efficiency between modified mRNA or pDNA
delivered by LPR (or LPD), we investigated the cellular uptake of LPR (or LPD) with Cy3-labeled …
delivered by LPR (or LPD), we investigated the cellular uptake of LPR (or LPD) with Cy3-labeled …