Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant
MS Kokoris, P Sabo, ET Adman, ME Black - Gene therapy, 1999 - nature.com
… herpes simplex virus type 1 (HSV-1) thymidine kinase gene.1,… the cellular thymidine kinase,
HSV-1 thymidine kinase (TK) is … Cellular kinases further phosphorylate the nucleotide to its …
HSV-1 thymidine kinase (TK) is … Cellular kinases further phosphorylate the nucleotide to its …
The role of herpes simplex virus type 1 thymidine kinase in pathogenesis
S Efstathiou, S Kemp, G Darby… - Journal of General …, 1989 - microbiologyresearch.org
… A genetically engineered herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) deletion
mutant has been constructed and used to investigate the role of this gene in pathogenesis. …
mutant has been constructed and used to investigate the role of this gene in pathogenesis. …
HSV-1 thymidine kinase promotes virulence and latency in the mouse.
YJ Gordon, DM Gilden, Y Becker - … ophthalmology & visual …, 1983 - iovs.arvojournals.org
… Different strains of HSV-1 have been shown to exist in nature, … The enzyme, thymidine kinase
(TK) plays an essential role in HSV-1 … Alteration in the HSV-1 thymidine kinase (TK) gene to …
(TK) plays an essential role in HSV-1 … Alteration in the HSV-1 thymidine kinase (TK) gene to …
Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: effects on catalytic activity
Q Liu, WC Summers - Virology, 1988 - Elsevier
… results of experiments with the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK)
in … The HSV-1 TK catalyzes the transfer of the r-phosphate of ATP to thymidine to form …
in … The HSV-1 TK catalyzes the transfer of the r-phosphate of ATP to thymidine to form …
Thymidine kinase deletion mutants of herpes simplex virus type 1
PG Sanders, NM Wilkie… - Journal of General …, 1982 - microbiologyresearch.org
… Deletions in the cloned thymidine kinase (TK) gene of herpes simplex virus type 1 (HSV-1), …
SstI and BglII restriction endonuclease sites of pTK1 (HSV-1 BamHI p cloned in pAT153) and …
SstI and BglII restriction endonuclease sites of pTK1 (HSV-1 BamHI p cloned in pAT153) and …
L-Thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth
… The aim of the present study was to verify whether Herpes simplex 1 thymidine kinase
would bind and process L-thymidine, the enantiomer of its natural substrate and whether this …
would bind and process L-thymidine, the enantiomer of its natural substrate and whether this …
Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation
MT Tomicic, R Thust, B Kaina - Oncogene, 2002 - nature.com
… The concept of HSVtk/GCV gene therapy is based on transduction of tumor cells with a ‘suicide
gene’ encoding the thymidine kinase of herpes simplex virus type 1 (HSVtk) or by …
gene’ encoding the thymidine kinase of herpes simplex virus type 1 (HSVtk) or by …
Expression of the Herpes simplex virus thymidine kinase gene in Saccharomyces cerevisiae
JB McNeil, JD Friesen - Molecular and General Genetics MGG, 1981 - Springer
… that carry the Herpes simplex Virus type 1 (HSV-1) thymidine kinase (TK) … thymidine kinase
activity which is absent in the original yeast strain. Yeast strains auxotrophic for thymidine …
activity which is absent in the original yeast strain. Yeast strains auxotrophic for thymidine …
… of pyrimidine deoxyribonucleoside kinase (thymidine kinase) and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes simplex virus type 1 …
MS Chen, WP Summers, J Walker… - Journal of …, 1979 - Am Soc Microbiol
… dylate kinase activity in cells infected with HSV1 with mutations in the TK gene, as well as
in cells stably transformed to the TK+ phenotype. In each case the activity of TMP kinase corre…
in cells stably transformed to the TK+ phenotype. In each case the activity of TMP kinase corre…
Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene
MA Swain, DA Galloway - Journal of Virology, 1983 - Am Soc Microbiol
… the thymidine kinase gene of herpessimplex virus (HSV) type 2 strain 333. The sequence of
the thymidine kinase … with that of the HSV type 1 thymidine kinase gene from strain MP (S. L. …
the thymidine kinase … with that of the HSV type 1 thymidine kinase gene from strain MP (S. L. …
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