… herpes simplex virus type 1 (HSV-1) thymidine kinase gene.1,… the cellular thymidine kinase,
HSV-1 thymidine kinase (TK) is … Cellular kinases further phosphorylate the nucleotide to its …

… A genetically engineered herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) deletion
mutant has been constructed and used to investigate the role of this gene in pathogenesis. …

… Different strains of HSV-1 have been shown to exist in nature, … The enzyme, thymidine kinase
(TK) plays an essential role in HSV-1 … Alteration in the HSV-1 thymidine kinase (TK) gene to …

… results of experiments with the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK)
in … The HSV-1 TK catalyzes the transfer of the r-phosphate of ATP to thymidine to form …

… Deletions in the cloned thymidine kinase (TK) gene of herpes simplex virus type 1 (HSV-1), …
SstI and BglII restriction endonuclease sites of pTK1 (HSV-1 BamHI p cloned in pAT153) and …

… The aim of the present study was to verify whether Herpes simplex 1 thymidine kinase
would bind and process L-thymidine, the enantiomer of its natural substrate and whether this …

… The concept of HSVtk/GCV gene therapy is based on transduction of tumor cells with a ‘suicide
gene’ encoding the thymidine kinase of herpes simplex virus type 1 (HSVtk) or by …

… that carry the Herpes simplex Virus type 1 (HSV-1) thymidine kinase (TK) … thymidine kinase
activity which is absent in the original yeast strain. Yeast strains auxotrophic for thymidine …

… dylate kinase activity in cells infected with HSV1 with mutations in the TK gene, as well as
in cells stably transformed to the TK+ phenotype. In each case the activity of TMP kinase corre…

… the thymidine kinase gene of herpessimplex virus (HSV) type 2 strain 333. The sequence of
the thymidine kinase … with that of the HSV type 1 thymidine kinase gene from strain MP (S. L. …