… Cyclin-dependent kinase inhibitor p21 is activated by p53 and halts the cell cycle. Once
activated, p21 indirectly influences transcriptional regulation and binds to TK1 [80]. Engeland …

… novel inhibitors of herpes simplex virus thymidine kinase (… 1), was found to be a potent,
nonsubstrate inhibitor of HSV-TK. l … inhibitor concentration at various thymidine concentrations. …

… Thymidine kinase 1 (TK1) and TK2 do not only differ in their … is virtually the only thymidine
kinase that is physiologically active in … human mitochondrial thymidine kinase inhibitors. Bioorg …

… Both thymidine kinases show … only thymidine kinase that is physiologically active in nonproliferating
and resting cells. Among natural deoxynucleosides, TK-1 phosphorylates thymidine (…

… evaluated as potential human mitochondrial thymidine kinase (TK-2) inhibitors. In this
series… thymidine kinase inhibitors. Our approach to the identification of new TK-2 inhibitors has …

… Consequently, the possibility that potential inhibitors would interfere with the appearance
of … with an excess of inhibitor into TK- cells. The thymidine kinase gene from herpes simplex …

… inhibition was reported to increase the thymidine kinase 1 (TK1) activity and nucleoside
transporter expression to regulate intracellular thymidine … kinetics following TS inhibition. In vitro …

… thymidine kinase with a Ki of 0.38 ,uM and showed no inhibition against human cytosolic
thymidine kinase … The compound was effective against the altered thymidine kinase induced by …

… Demonstration of viral thymidine kinase inhibitor and its effect on … inhibitor of Herpes simplex
thymidine kinase. J. Med. … and selective inhibitors of Herpes simplex virus thymidine kinase. …

The regulation of thymidine (TdR) kinase synthesis in synchronized cultures of KB cells was
studied. The enzyme was found to undergo periodic increases and decreases in activity …