… Nucleoside analogues are prodrugs, requiring 5'-phosphorylation to form … kinases. This
mini-review attempts to summarize the biochemistry of the pyrimidine specific thymidine kinase …

… thymidine kinase (TK1), deoxycytidine kinase (dCK) and mitochondrial thymidine kinase (…
and their capacities to phosphorylate 43 nucleoside analogs were compared. TK1 showed the …

… nucleosides and nucleoside analogues, thymidine kinases … of antiviral or anticancer
nucleoside analogues. Recently, … anti-hepatitis B virus nucleoside analogue FIAU 8 or with the …

… We describe the use of nonpolar nucleoside analogues of systematically varied size and …
thymidine kinases (TK1 and TK2) recognize and phosphorylate their substrate, thymidine. …

… then converted by intracellular kinases into the … nucleoside analogues. In the particular case
in which TMPK is the drug target, a thymidine (dT) analogue could be activated by thymidine …

… Most of these analogs are capable of being phosphorylated by both human and viral …
determined for these analogs with the same thymidine kinases. In general, these analogs have a …

… nucleoside derivatives have been described. Very recently, we have reported on the first
acyclic nucleoside analogues … Further studies with this compound and related analogues have …

… ABSTRACT: Nucleoside analogues with … kinase (dCK) and thymidine kinases (tetrameric
high-affinity form of TK1, and TK2) from human leukemic spleen. In particular, the analogues …

… thymidine kinase (TK) and cellular deoxycytidine kinase … -nucleoside analogues as antiviral
drugs (Herpes, hepatitis and immunodeficiency viruses). Several -nucleoside analogues …

… kinases thymidine kinase 1 and 2, deoxycytidine kinase and deoxyguanosine … nucleoside
analogs. These four salvage kinase enzymes exhibit distinct substrate specificities for …