… used as oral anti-cancer drugs in combination with thymidine phosphorylase inhibitor in the
treatment of refractory colorectal cancer. [ Citation 26 ] Upon uptake into the cells TFT can be …

… Resistance to nucleoside analogues is in general conferred by direct alterations in (…
Decreased cellular uptake through nucleoside transporters and increased export by multidrug …

… against thymidine kinase-2 (TK-2) and related nucleoside kinases [ie, Drosophila melanogaster
deoxynucleoside kinase (Dm-dNK) and herpes simplex virus type 1 thymidine kinase (…

… thymidine uptake was not affected. The activities of enzymes in the salvage of thymidine and
deoxyuridine, eg, thymidine kinase … may explain the increased uptake of deoxyuridine and …

… increased significantly but thymidine kinase and ATP levels … for the type-1 equilibrative
nucleoside transporter (ENT). There … ]FLT uptake, we examined induced versus uninduced uptake …

… Extensive preclinical studies of the reporter gene Herpes simplex viral thymidine kinase 1
(… in vitro uptake assays of five reporter probes to compare four human nucleoside reporter …

… may be a consequence of increased uptake of nutrients into the … Nucleoside analogs of
thymidine do effectively prevent … Our results indicate that nucleoside analogs of thymidine should …

… in cellular content of nucleoside kinases also must contribute impor tantly to cycle-dependent
fluctuations in nucleoside uptake. Increased activity of thymidine kinase has long been con …

… selectivity, between radiotracer uptake in HSV1-tk expressing cells and that in HSV1-tk-negative
cells. The uptake selectivity indices among the six different nucleosides, as determined …

… of nucleoside analogs by the types I and II thymidine kinase (… for the activation of these
nucleoside analogs. This differs from … that the inefficient activation of nucleoside analogs by the …