[PDF][PDF] Thymidine kinase with altered substrate specificity of acyclovir resistant varicella-zoster virus
K Shiraki, T Ogino, K Yamanishi… - Biken journal: journal …, 1986 - ir.library.osaka-u.ac.jp
K Shiraki, T Ogino, K Yamanishi, M Takahashi
Biken journal: journal of Research Institute for Microbial Diseases, 1986•ir.library.osaka-u.ac.jpKawaguchi strain. flowever, it induced less deoxycytidine kinase activit and did not induce
phosphorylating activity for the nucleotide analogue, 9-(2 hydroxy-etlToxymethyl)~ guanine-
(acyclovir). Another acyclovir resistant mutant, ACV-R (A 4),\\, hich is cross-resistant to
phDsphonoacetate and is thought to be a viral DNA polymerase mutant, induced the same
level of phosphorylating activities for thymidine, deoxycytidine and acyclovir as the parent
strain. The altered substrate specificity of thymidine kinas, induced by ACV-R (A 8) is c. rich …
phosphorylating activity for the nucleotide analogue, 9-(2 hydroxy-etlToxymethyl)~ guanine-
(acyclovir). Another acyclovir resistant mutant, ACV-R (A 4),\\, hich is cross-resistant to
phDsphonoacetate and is thought to be a viral DNA polymerase mutant, induced the same
level of phosphorylating activities for thymidine, deoxycytidine and acyclovir as the parent
strain. The altered substrate specificity of thymidine kinas, induced by ACV-R (A 8) is c. rich …
Kawaguchi strain. flowever, it induced less deoxycytidine kinase activit and did not induce phosphorylating activity for the nucleotide analogue, 9-(2 hydroxy-etlToxymethyl)~ guanine-(acyclovir). Another acyclovir resistant mutant, ACV-R (A 4),\\, hich is cross-resistant to phDsphonoacetate and is thought to be a viral DNA polymerase mutant, induced the same level of phosphorylating activities for thymidine, deoxycytidine and acyclovir as the parent strain. The altered substrate specificity of thymidine kinas, induced by ACV-R (A 8) is c. rich, ded to c, rife" resistance to acyclovir on ACV-R (A 8)
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