… Extended mutational profiling of advanced thyroid cancers may enhance considerations
for targeted therapies. We analyzed clinically derived molecular profiling of 216 patients with …

… thyroid cancers as follicular-cell-derived thyroid cancers with … mutational status and functional
groups of somatic mutations … identifying the mutations in advanced thyroid cancers and for …

… (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (…
RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to …

… expression profile changes associated with different mutations that contribute to thyroid …
(2006) for an overview of genetic alterations involved in the development of thyroid cancer). …

… The different mutational profiles of driver genes between the subtypes of thyroid cancer might
explain the heterogeneity of thyroid cancer, as well as the individual differences. Therefore…

… As the genetic profiles of thyroid cancer vary dramatically … found that TERTp mutational status
defined thyroid cancer with poor … , and aggressive cancer types. The occurrence of TERTp …

… determine if the mutational profile of T4 cancers was distinct … dedifferentiated or anaplastic
cancers associated with distant … well differentiated T4 thyroid cancers have mutations in BRAF …

… with thyroid cancer. All the thyroid cancer cases were classic papillary thyroid cancer. Thus,
… Our results for BRAF V600E and NRAS mutations in FNMTC cases are similar to the results …

… mutational clonality of thyroid cancers. (A) Tumor mutational burden comparisons between
papillary thyroid … differentiated thyroid carcinomas (PDTCs), anaplastic thyroid carcinomas (…

… Indeed, the development of whole exome sequencing and next-generation sequencing
modalities have shed new light on the major oncogenic mutations that drive thyroid cancer, …