… thyroid carcinomas (WDTC) and include two main subtypes: … thyroid carcinoma (PTC) and
follicular thyroid carcinoma (FTC… thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (…

… MAPK signaling pathway is physiologically activated by binding of growth factors to receptor
tyrosine kinases (RTKs), such as RET and NTRK, resulting in receptor dimerization and …

… signaling leads to the activation of the RAS/mitogen-activated protein kinase (MAPK) and the
phosphatidylinositol 3′ kinase (PI3K)/Akt pathways … cellular signaling pathways other than …

… implicated in thyroid pathology. In this review we focus on the different signaling
pathways involved in TSH-mediated proliferation and their role in thyroid transformation and …

… pathways implicated in key cellular processes. Its continuous activation by … thyroid
carcinomas. In this review article, the role of different signaling pathways of PI3K/AKT in thyroid …

… carcinomas may … signaling pathways. These distinct genetic alterations constitutively
activate the MAPK, PI3K and β-catenin signaling pathways, which have been implicated in thyroid …

… (PI3K)/protein kinase B (AKT) signaling pathway. Inhibition of PI3K activity by its inhibitor
LY294002 abrogated leptin-mediated PI3K/AKT signaling. Gene silencing of Ob-R in PTC cells …

… Because these signaling proteins function along the same pathway in thyroid cells, this
represents a unique paradigm of human tumorigenesis through mutation of three signaling …

… thyroid carcinoma (MTC) over the last 55 years has led to a good understanding of the genetic
defects and altered molecular pathways … newly understood molecular pathways and the …

… methods that the Hh pathway can be easily manipulated through the canonical signaling
pathway. Our results also suggest that inhibition of Hh signaling reduces cell number and …