… of BRAF exon 15 in 100 samples from thyroid tissue surrounding 30 randomly selected
PTCs to better understand the mutagenic process that leads to BRAF p.V600E mutated PTCs. …

… or MEC, or in the thyroid parenchyma adjacent to the tumours, … exon 15 of BRAF but in a
different codon (nucleotide 1798 AG changing a lysine for a glutamic acid in codon 600 — BRAF …

… mutations involve a thymine to adenine transversion (T1799A) in exon 15, resulting in a …
Intravascular tumour emboli diffusely infiltrate the thyroid parenchyma. PTCs with the BRAF …

… (SSCP) analysis: PCR reaction products of BRAF exons 11 and 15 were diluted 1:1 with
loading … ” thyroid parenchyma adjacent to PTC, regardless of the presence or absence of BRAF …

… The T1799A mutation in BRAF exon 15 leads to a substitution of V for E at residue 600 in …
thyroid parenchyma through infiltration or fibrosis and is the most common inflammatory thyroid …

… d Resected thyroid nodule demonstrating invasive growth into thyroid parenchyma. Note …
tissue revealing a heterozygous point mutation of BRAF in exon 15 (GTG to GAG) resulting in …

… the BRAF gene located on exon 15 … thyroid parenchyma and strap muscles and was classified
as hyperechoic, isoechoic, or hypoechoic compared with the normal thyroid parenchyma, …

… microdissection from the adjacent parenchyma. DNA was … initial restriction of the BRAF
mutations in thyroid tumors to the … presence of this or other mutations in exon 15 of BRAF gene. …

… Samples from the nonneoplastic thyroid parenchyma, … PCR primers for the BRAF exon 15
were as follows: forward, … with those of the normal BRAF gene exon 15 by using the Basic …

… , 2 spatially different tumor and adjacent thyroid parenchyma tissue sections were excised by
… We targeted BRAF mutations at exon 15 for polymerase chain reaction (PCR) amplification …