… in a normal rat thyroid PCCL3 cell line results in a significant up-regulation of cellular
proliferation of these thyroid cells and promotes their thyrotropin (thyroid-stimulating hormone, TSH)…

… Here, we report that RET/PTC3 oncogenic activation in PCCL3 rat thyroid cells markedly
reduces let-7f expression. Moreover, stable transfection of let-7 microRNA in TPC-1 …

… 5 cell line when compared with the PCCL3 cells… cells was significantly greater than that in
PCCL3 cells (P<0.05). After PDTC treatment, RET/PTC expression in PTC3-5 and PCCL3 cells …

… as compared to normal cells. We found that normal thyroid derived cells presented a higher
ability … in normal thyroid cells Nthy-1, FRTL-5 and PCCL3 cells, as compared to PTC-derived …

… biology, we overexpressed the miR-17-92 cluster in normal rat thyroid follicular cells
PCCl3 (stable cell line PCCl3-miR-17-92) (Fig. 4A). miR-17-92 overexpression increased …

… Crocin did not show toxicity to the normal thyroid (PCCL3) cells. Crocin-induced reactive
oxygen species, mitochondrial membrane potential activity, caspase-8 and -9, lipid …

… Moreover, our work suggests that iodide release by the thyroid PCCl3 and FRTL-5 cells
reproduces the characteristics of ANO1 but not those of pendrin. Whereas release of iodide by …

… similar in both cell lines, we focused on PCCl3 cells in the … Although PCCl3 and FRTL5
thyroid cells express various … only Wnt7A was detected in FRTL5 cells (Supplemental Figure 1). …

… , TGF-β decreases RAIU (14,15), and we have confirmed the same in PCCl3 cells (data
not shown). TGF-β induces EMT (16–18), yet Akt inhibition decreases EMT (19–23). Taken …

… Human thyroid cell cultures and PCCl3 cells were scraped in ice-cold RIPA lysis buffer (50
mM Tris-HCl, pH 7.4, 150 mM NaCl, 1% NP-40, 0.25% sodium desoxycholate, supplemented …