Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma
C Granier, C Dariane, P Combe, V Verkarre, S Urien… - Cancer research, 2017 - AACR
… Notably, other CD8 + T-cell subsets did not … Tim-3 + subset of CD8 + T cells exhibited
impaired function after stimulation. Our findings establish intratumoral Tim-3 + PD1 + CD8 + T cells …
impaired function after stimulation. Our findings establish intratumoral Tim-3 + PD1 + CD8 + T cells …
[HTML][HTML] Tim-3 expression and its role in hepatocellular carcinoma
F Liu, Y Liu, Z Chen - Journal of hematology & oncology, 2018 - Springer
… targeting anti-carbonic anhydrase IX and secreting anti-PD-L1 antibodies, effectively
suppressing renal cell carcinoma in a humanized mouse model. Rupp et al. [90] developed PD-1-…
suppressing renal cell carcinoma in a humanized mouse model. Rupp et al. [90] developed PD-1-…
The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas
Y Komohara, T Morita, DA Annan, H Horlad… - Cancer immunology …, 2015 - AACR
… relevance of T-cell immunoglobulin and mucin domain-… -3 (TIM-3) expressed on tumor
cells and myeloid cells in patients with ccRCC. TIM-3 expression was detected on cancer cells …
cells and myeloid cells in patients with ccRCC. TIM-3 expression was detected on cancer cells …
Tim‐3 and its role in regulating anti‐tumor immunity
M Das, C Zhu, VK Kuchroo - Immunological reviews, 2017 - Wiley Online Library
… NSCLC, melanoma, and renal cell carcinoma (RCC), with … Furthermore, some tumors,
such as colorectal carcinomas, … receptors for inducing T cell dysfunction and inhibiting anti-tumor …
such as colorectal carcinomas, … receptors for inducing T cell dysfunction and inhibiting anti-tumor …
[HTML][HTML] LAG-3, TIM-3 and VISTA Expression on Tumor-Infiltrating Lymphocytes in Oropharyngeal Squamous Cell Carcinoma—Potential Biomarkers for Targeted …
N Wuerdemann, K Pütz, H Eckel, R Jain… - International journal of …, 2020 - mdpi.com
… -domain containing-3 (TIM-3) and V-domain Ig suppressor of T cell activation (VISTA) … cell
carcinoma (OPSCC) are lacking. This work aims to describe the expression of LAG-3, TIM-3, …
carcinoma (OPSCC) are lacking. This work aims to describe the expression of LAG-3, TIM-3, …
[HTML][HTML] TIM-3 is a potential prognostic marker for patients with solid tumors: A systematic review and meta-analysis
Y Zhang, P Cai, T Liang, L Wang, L Hu - Oncotarget, 2017 - ncbi.nlm.nih.gov
… cancers involving: bladder urothelial carcinoma (BUC), non–small cell lung cancer (NSCLC), …
B virus-associated hepatocellular carcinoma and clear cell renal cell carcinoma. The …
B virus-associated hepatocellular carcinoma and clear cell renal cell carcinoma. The …
[HTML][HTML] Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
K Takamatsu, N Tanaka, K Hakozaki… - Nature …, 2021 - nature.com
… single-cell count for immunolabelled LAG-3, TIM-3, and TIGIT… biomarkers for profiling human
renal cell carcinoma (RCC). … for discriminating the LAG-3, TIM-3, and TIGIT tumour profiles…
renal cell carcinoma (RCC). … for discriminating the LAG-3, TIM-3, and TIGIT tumour profiles…
Tim-3 expression represents dysfunctional tumor infiltrating T cells in renal cell carcinoma
C Cai, YF Xu, ZJ Wu, Q Dong, MY Li, JC Olson… - World journal of …, 2016 - Springer
… Also, GATA-3 and interferon gamma (IFN-γ) were down-regulated, whereas T-bet … Tim-3+
T cells, indicating that Tim-3 expression defined a population of dysfunctional TIL Th1/Tc1 cells…
T cells, indicating that Tim-3 expression defined a population of dysfunctional TIL Th1/Tc1 cells…
[HTML][HTML] Tim-3 expression defines regulatory T cells in human tumors
… However, the nature and role of Tim-3 + CD4 T cells in human tumors … Tim-3 + CD4 T
cells in 100 specimens from human hepatocellular, cervical, colorectal and ovarian carcinoma …
cells in 100 specimens from human hepatocellular, cervical, colorectal and ovarian carcinoma …
Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers
OK Afanasiev, L Yelistratova, N Miller, K Nagase… - Clinical cancer …, 2013 - AACR
… T cells and MCC-infiltrating lymphocytes expressed higher levels of therapeutically targetable
PD-1 and Tim-3 inhibitory receptors compared with T cells … -targeting T cells expand with …
PD-1 and Tim-3 inhibitory receptors compared with T cells … -targeting T cells expand with …