… Notably, other CD8 + T-cell subsets did not … Tim-3 + subset of CD8 + T cells exhibited
impaired function after stimulation. Our findings establish intratumoral Tim-3 + PD1 + CD8 + T cells …

… targeting anti-carbonic anhydrase IX and secreting anti-PD-L1 antibodies, effectively
suppressing renal cell carcinoma in a humanized mouse model. Rupp et al. [90] developed PD-1-…

… relevance of T-cell immunoglobulin and mucin domain-… -3 (TIM-3) expressed on tumor
cells and myeloid cells in patients with ccRCC. TIM-3 expression was detected on cancer cells …

… NSCLC, melanoma, and renal cell carcinoma (RCC), with … Furthermore, some tumors,
such as colorectal carcinomas, … receptors for inducing T cell dysfunction and inhibiting anti-tumor …

… -domain containing-3 (TIM-3) and V-domain Ig suppressor of T cell activation (VISTA) … cell
carcinoma (OPSCC) are lacking. This work aims to describe the expression of LAG-3, TIM-3, …

… cancers involving: bladder urothelial carcinoma (BUC), non–small cell lung cancer (NSCLC), …
B virus-associated hepatocellular carcinoma and clear cell renal cell carcinoma. The …

… single-cell count for immunolabelled LAG-3, TIM-3, and TIGIT… biomarkers for profiling human
renal cell carcinoma (RCC). … for discriminating the LAG-3, TIM-3, and TIGIT tumour profiles…

… Also, GATA-3 and interferon gamma (IFN-γ) were down-regulated, whereas T-bet … Tim-3+
T cells, indicating that Tim-3 expression defined a population of dysfunctional TIL Th1/Tc1 cells…

… However, the nature and role of Tim-3 + CD4 T cells in human tumors … Tim-3 + CD4 T
cells in 100 specimens from human hepatocellular, cervical, colorectal and ovarian carcinoma …

… T cells and MCC-infiltrating lymphocytes expressed higher levels of therapeutically targetable
PD-1 and Tim-3 inhibitory receptors compared with T cells … -targeting T cells expand with …