Fast fluorescence lifetime imaging techniques: A review on challenge and development

X Liu, D Lin, W Becker, J Niu, B Yu, L Liu… - Journal of Innovative …, 2019 - World Scientific
… There are FLIM techniques recording in the time domain and in the frequency domain,
scanning techniques and wide-field techniques, and analog-recording and photon counting …

Optimizing frequency-domain fluorescence lifetime sensing for high-throughput applications: photon economy and acquisition speed

A Esposito, HC Gerritsen, FS Wouters - JOSA A, 2007 - opg.optica.org
… efficiency of various frequency-domain lifetime detection techniques also in relation to time-…
Lifetime detection can be performed in the time domain (TD) and in the frequency domain (FD…

Fluorescence lifetime imaging techniques for microscopy

T French, PTC So, CY Dong, KM Berland… - Methods in Cell Biology, 1998 - Elsevier
Time-resolved fluorescence measurements are performed in two functionally equivalent ways:
using the time domain or the frequency domain. … error of the fluorescence lifetime imaging …

Global analysis of fluorescence lifetime imaging microscopy data

PJ Verveer, A Squire, PIH Bastiaens - Biophysical journal, 2000 - cell.com
… For time domain measurements, this can be achieved by sampling the response to a light
pulse and fitting a multiexponential function to the measurements. This approach was …

Fluorescence lifetime imaging microscopy (FLIM): spatial resolution of microstructures on the nanosecond time scale

TWJ Gadella Jr, TM Jovin, RM Clegg - Biophysical chemistry, 1993 - Elsevier
… of the problems associated with the direct time-domain measurements. The method is under …
of a lifetime-resolved fluorescence microscope operating in the nanosecond time domain . …

Dual lifetime referencing (DLR)—a new scheme for converting fluorescence intensity into a frequency-domain or time-domain information

I Klimant, C Huber, G Liebsch, G Neurauter… - … trends in fluorescence …, 2001 - Springer
Lifetime Referencing (DLR). When using a phosphorescent luminophore as the reference
dye, the time domain … , the fundamentals of time-domain DLR and frequency-domain DLR are …

Spectrally resolved fluorescence lifetime imaging microscopy

QS Hanley, DJ Arndt-Jovin, TM Jovin - Applied Spectroscopy, 2002 - opg.optica.org
time domain lifetime system (TimeMaster; Photon Technology International, Monmouth, NJ).
The time domain lifetime … A global analysis of the time domain data at all wavelengths to a …

Optimized protocol of a frequency domain fluorescence lifetime imaging microscope for FRET measurements

A Leray, FB Riquet, E Richard, C Spriet… - Microscopy research …, 2009 - Wiley Online Library
… We identify several sources of lifetime precision degradation … , we demonstrate fluorescence
lifetime measurements … lifetimes measurements realized either with the time domain (…

Compressive hyperspectral time-resolved wide-field fluorescence lifetime imaging

Q Pian, R Yao, N Sinsuebphon, X Intes - Nature photonics, 2017 - nature.com
… of fluorescence lifetime-based biomarkers. As an intrinsic characteristic of a fluorophore and
its state, fluorescence lifetime … ) 10,11 with robustness because lifetime measurements are …

A time-resolved CMOS image sensor with draining-only modulation pixels for fluorescence lifetime imaging

Z Li, S Kawahito, K Yasutomi, K Kagawa… - … on Electron Devices, 2012 - ieeexplore.ieee.org
… Abstract—This paper presents a time-resolved CMOS image … , for timedomain fluorescence
lifetime imaging. In the DOM pixels using a pinned photodiode (PPD) technology, a time-…