In vitro vascularization of tissue engineered constructs by non-viral delivery of pro-angiogenic genes

HR Moreira, RM Raftery, LP da Silva… - Biomaterials …, 2021 - pubs.rsc.org
… In the context of tissue regeneration, the formation of capillary… we hypothesized that delivering
genes-encoding angiogenic … , cells produced functional pro-angiogenic proteins which …

Pro-angiogenic impact of SDF-1α gene-activated collagen-based scaffolds in stem cell driven angiogenesis

AL Laiva, RM Raftery, MB Keogh, FJ O'Brien - International journal of …, 2018 - Elsevier
… Currently, within scaffold based tissue engineering, one of the greatest … of the
constructs in order to achieve functional tissue repair. Functionalizing the scaffolds with pro-angiogenic

Tissue-engineered 3D tumor angiogenesis models: potential technologies for anti-cancer drug discovery

K Chwalek, LJ Bray, C Werner - Advanced drug delivery reviews, 2014 - Elsevier
… that tumor cells significantly increase expression of pro-angiogenic genes in response to
co-culture … As microscopy will remain the major analysis route of tissue engineered constructs

Angiogenesis in tissue engineering: as nature intended?

V Mastrullo, W Cathery, E Velliou… - … in bioengineering and …, 2020 - frontiersin.org
… on the development of tissue engineered constructs, solutions … to generate tissue engineered
constructs embedded with … increase in concentration of pro-angiogenic factors produced by …

Angiogenic potential of tissue engineered cartilage from human mesenchymal stem cells is modulated by Indian hedgehog and serpin E1

Y Nossin, E Farrell, WJLM Koevoet… - … in Bioengineering and …, 2020 - frontiersin.org
… To understand the role of these factors in the pro-angiogenic … the dataset with a list of genes
we previously determined with … of BMSC-derived cartilaginous constructs, which are known …

Promoting angiogenesis in engineered tissues

KH Bouhadir, DJ Mooney - Journal of drug targeting, 2001 - Taylor & Francis
… vascularization in the field of tissue engineering. It will be mainly … molecules with the
cell-polymer construct in order to induce … fabricated to deliver pro-angiogenic macromolecules, …

[HTML][HTML] Tissue-engineered pro-angiogenic fibroblast scaffold improves myocardial perfusion and function and limits ventricular remodeling after infarction

JR Fitzpatrick III, JR Frederick, RC McCormick… - The Journal of thoracic …, 2010 - Elsevier
… Alternatively, viral gene transfer may achieve greater efficacy … , 21 the current study uses a
tissue-engineered, 3-dimensional … Although this work is promising, our study builds on these …

Surface engineering of 3D-printed scaffolds with minerals and a pro-angiogenic factor for vascularized bone regeneration

J Lee, SJ Huh, JM Seok, S Lee, H Byun, GN Jang… - Acta Biomaterialia, 2022 - Elsevier
… promoted the secretion of pro-angiogenic factors. Cells cultured … composed of minerals and
pro-angiogenic growth factor, … The relative values of fold changes in gene expression in the …

Genetically engineered angiogenic cell sheets using magnetic force-based gene delivery and tissue fabrication techniques

H Akiyama, A Ito, Y Kawabe, M Kamihira - Biomaterials, 2010 - Elsevier
… A major limitation in tissue engineering is the insufficient formation of blood … tissues with
low cell densities. Thus, the development of pro-angiogenic, tissue-engineered constructs is an …

Vascularisation of tissue-engineered grafts: the regulation of angiogenesis in reconstructive surgery and in disease states

CSO Cassell, OPS Hofer, WA Morrison… - British journal of plastic …, 2002 - Elsevier
… essential components of tissueengineered constructs are … constant or repeated doses of
pro-angiogenic growth factor. It is … local, systemic or through gene therapy of the host cell, has to …