Cell competition in vertebrates—A key machinery for tissue homeostasis

T Maruyama, Y Fujita - Current Opinion in Genetics & Development, 2022 - Elsevier
… of cell competition have been considerably revealed. For instance, upon cell competition,
loser cells are eliminated from tissues … , including apoptosis, cell differentiation, and cell death-…

Cell competition in development, homeostasis and cancer

SM van Neerven, L Vermeulen - Nature Reviews Molecular Cell …, 2023 - nature.com
… This Review discusses the latest insights into the mechanisms of cell competition and its …
Importantly, cell competition in tissue homeostasis is often studied in stem cell-driven tissues

Picking winners and losers: cell competition in tissue development and homeostasis

W Kim, R Jain - Trends in Genetics, 2020 - cell.com
… of cell competition contributes to disease. In this section, we specifically discuss the role
of cell competition in progenitor cells, tumorigenesis, tissue homeostasis, and aging. …

Cooperation and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis

A Csikász-Nagy, LM Escudero, M Guillaud… - Seminars in cancer …, 2013 - Elsevier
cell-to-cell communication that can capture the interplay between cellular competition and
tissue … the possible uses of this approach in modelling tumorigenesis and tissue homeostasis. …

[HTML][HTML] Cell competition and the regulation of protein homeostasis

S Krishnan, PK Paul, TA Rodriguez - Current Opinion in Cell Biology, 2024 - Elsevier
… of cell competition as a fitness sensing mechanism The regulation of tissue homeostasis is
profoundly impacted by cellular … protein homeostasis are key to the cell's competitive abilities. …

Competition for stem cell fate determinants as a mechanism for tissue homeostasis

DJ Jörg, Y Kitadate, S Yoshida, BD Simons - arXiv preprint arXiv …, 2019 - arxiv.org
competition for fate determinants provides a generic and robust mechanism by which stem
cells can self-organize to achieve density homeostasis … , stem cells compete for limited niche …

Stem cell competition orchestrates skin homeostasis and ageing

N Liu, H Matsumura, T Kato, S Ichinose, A Takada… - Nature, 2019 - nature.com
… The COL17A1-dependent self-renewal of epidermal stem cells by parallel SCDs explains
the higher fitness of COL17A1 + stem cell clones in cell competition during tissue homeostasis

Compensatory cellular hypertrophy: the other strategy for tissue homeostasis

Y Tamori, WM Deng - Trends in cell biology, 2014 - cell.com
… A crucial mechanism for tissue homeostasis involves cellcells are regularly eliminated and
replaced by new cells … postmitotic cell competition, however, the neighboring wild type cells

Distinct modes of cell competition shape mammalian tissue morphogenesis

SJ Ellis, NC Gomez, J Levorse, AF Mertz, Y Ge… - Nature, 2019 - nature.com
… that cell competition is a selective force that optimizes vertebrate tissue function, and illuminate
how a tissue … is not yet clear, and we do not know whether cell competition functions in …

Cell competition: mechanisms and physiological roles

C Clavería, M Torres - Annual review of cell and developmental …, 2016 - annualreviews.org
… populations induced by CC entail important changes in cellular properties, tissue
homeostasis is preserved, without obvious alterations to organ size or morphology. Given the …