Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

E Maury, SM Brichard - Molecular and cellular endocrinology, 2010 - Elsevier
… This dysregulation of adipokine production may promote … adipokines, this review will also
highlight the cellular key players and molecular mechanisms involved in adipose inflammation. …

Adipokine dysregulation and adipose tissue inflammation in human obesity

X Unamuno, J Gómez‐Ambrosi… - European journal of …, 2018 - Wiley Online Library
… secretion of adipokines. This review describes how adipose tissue becomes inflamed in …
and summarizes key players and molecular mechanisms involved in adipose inflammation. …

Adipose tissue and adipocyte dysregulation

M Lafontan - Diabetes & metabolism, 2014 - Elsevier
Inflammation in adipose tissue (AT) is one mechanism proposed to explain the … adipocytes
that begin an inflammatory campaign of altered adipokine and cytokine secretions. Adipocyte …

The role of adipokines in chronic inflammation

P Mancuso - ImmunoTargets and therapy, 2016 - Taylor & Francis
… Among the endocrine factors elaborated by adipose tissue are the adipokines; hormones, …
inflammation. This review focuses on the ability of adipokines to regulate the inflammatory

Adipokines in inflammation and metabolic disease

N Ouchi, JL Parker, JJ Lugus, K Walsh - Nature reviews immunology, 2011 - nature.com
Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction
… In this Review, we focus on the role of adipokines in inflammatory responses and discuss …

Adipokines mediate inflammation and insulin resistance

H Kwon, JE Pessin - Frontiers in endocrinology, 2013 - frontiersin.org
… The dysregulation of adipokines has been implicated in obesity, type 2 diabetes, and
cardiovascular disease. Recently, inflammatory responses in adipose tissue have been shown as …

Adipokines, hepatokines and myokines: focus on their role and molecular mechanisms in adipose tissue inflammation

Y Ren, H Zhao, C Yin, X Lan, L Wu, X Du… - Frontiers in …, 2022 - frontiersin.org
Adipokines, hepatokines and … AT inflammation via endocrine, paracrine, and autocrine
pathways. For example, obesity is associated with elevated levels of pro-inflammatory adipokines

Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet …

EY Kwon, SK Shin, YY Cho, UJ Jung, E Kim, T Park… - BMC genomics, 2012 - Springer
… Thus, adipokine dysregulation may also regulate remodeling of the adipocyte … of adipokine
dysregulation, inflammation, ECM accumulation leading to the development of adipose tissue

Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes

B Wang, IS Wood, P Trayhurn - Pflügers Archiv-European Journal of …, 2007 - Springer
… The production of a number adipokines increases during the expansion of adipose tissue
PAI-1), with the result that there is an inflammatory state within the tissue [11, 14, 26, 38]. An …

Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?

P Trayhurn, B Wang, IS Wood - British Journal of Nutrition, 2008 - cambridge.org
… White adipose tissue is a key … adipokines, many of which are linked to inflammation and
immunity. During the expansion of adipose tissue mass in obesity there is a major inflammatory