… Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

… , a punctual tissue injury (injury 1) to the liver awakens a regenerative … injuries (injuries
1 + 2) hinder regeneration and make the system drift into a diseased state known as fibrosis …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

… the true underpinnings of tissue homeostasis, injury repair, and fibrosis. Recognition of tissue
injury and recruitment of inflammatory cells to sites of tissue injury is a fundamental aspect …

… Repair and regeneration develop following inflammatory responses, inflammation itself
being the primary response to tissue injury (see Chapter 2). To understand how inflammation …

… ► Fibrosis was selected throughout evolution because of its … to fibrosis because they
contribute to all phases of tissue injury … tissue inflammation and promoting tissue regeneration are …

… fibrosis formation. Fibrous scar tissue is a potential factor that impedes muscle regeneration
… vascular perfusion of the injury site, subsequently leading to incomplete functional recovery. …

… disorders, results in liver fibrosis, often leading to cirrhosis and … resulting in either regeneration
or fibrosis. In addition, chronic … regeneration and fibrosis in the viewpoint of inflammation. …

… fibrotic repair, but can also restore damaged kidney tissue. Mobilizing this innate capacity of
the kidney to regenerate is of … tissue homeostasis and the balance between tissue repair and …

… patterns of tissue injury, but kidney atrophy in CKD involves tissue remodeling with interstitial
inflammation and scarring. No doubt, nephron atrophy, inflammation, fibrosis, and renal …