… Diagram of the correlations identified between different macrophage populations in
rheumatoid synovium. The macrophage markers studied were CD68, CD14, RFD7, and Ber-MAC3. …

… epidermis, tissue-resident macrophages are embryo-derived. In adulthood, these embryo-derived
macrophage populations can maintain themselves by self-renewal 32 . By contrast, …

… of macrophages, the tissue-resident macrophage population … of this macrophage population
for tissue homeostasis. … similarities with human alveolar macrophages that also express …

… STM populations during development and resolution of arthritis, we performed unbiased
scRNA-seq, followed by validation with flow cytometry and immunofluorescent IHC staining, of …

… Initially thought to be replaced by circulating bone marrow-derived monocytes, we now
know that most tissue-resident macrophage populations are established prior to birth during …

… Rheumatoid arthritis (RA) is among the most common autoimmune disorders, affecting 1–2%
of the population … of scattered macrophages within a fibroblast stromal tissue and scarce …

… This approach has two advantages: (a) striking the cell population that mediates/amplifies
most of the irreversible tissue destruction and (b) sparing other cells that have no (or only …

… populations in synovial membrane biopsies obtained before treatment from patients with
rheumatoid arthritis (… Conclusion-This study suggests that synovial tissue macrophages play a …

… Furthermore, these new technological approaches have broadened our understanding of
disease pathophysiology and the diversity of cell populations within the synovial tissue, …

… Autoaggressive dedifferentiated synoviocytes, loss of tissue-protective macrophage
populations and T cell pyroptosis drive joint damage. The loss of tissue tolerance is irreversible in …