Adipose tissue macrophages in obesity, inflammation, and cancer

CNK Lumeng - Obesity, Inflammation and Cancer, 2013 - Springer
obesity modifies cancer risk. This review will summarize the current understanding of adipose
tissue macrophages (… diversity in adipose tissue and how this is altered by obesity. In this …

[HTML][HTML] Adipose tissue immunity and cancer

V Catalán, J Gómez-Ambrosi, A Rodríguez… - Frontiers in …, 2013 - frontiersin.org
… The observation of infiltrated macrophages in the adipose tissue of obese patients prompted
… activation of adipose tissue macrophages, resulting in increased inflammation in adipose …

[HTML][HTML] Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages

D Okwan-Duodu, GE Umpierrez… - … journal of cancer …, 2013 - ncbi.nlm.nih.gov
… which different aspects of obesity, namely insulin resistance… tissue macrophages, may
coalesce to promote MDSC induction and M2 macrophage polarization, thereby facilitating cancer

The obese adipose tissue microenvironment in cancer development and progression

DF Quail, AJ Dannenberg - Nature Reviews Endocrinology, 2019 - nature.com
… Interestingly, in preclinical models of breast cancer, tumour-associated macrophages
tissue macrophages 59 . The population of CD11c + macrophages accelerates breast cancer

[HTML][HTML] Pancreatic macrophages: critical players in obesity-promoted pancreatic cancer

Y Teper, G Eibl - Cancers, 2020 - mdpi.com
… The percentage of adipose tissue macrophages (ATMs) increases from about 10% of all …
50% in severe obesity in mice [29,31]. The increase of macrophage numbers in obese AT is …

Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity

LK Heilbronn, LV Campbell - Current pharmaceutical design, 2008 - ingentaconnect.com
… syndrome, type 2 diabetes and some types of cancers. … tissue macrophages (ATMs) are the
main source of the increase in the circulating inflammatory molecules detected in obesity [12, …

[HTML][HTML] Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation

SU Amano, JL Cohen, P Vangala, M Tencerova… - Cell metabolism, 2014 - cell.com
macrophage proliferation increases with obesity in tissues other than AT, we analyzed the
proliferation rate of macrophages … of adipose tissue macrophages with obesity is generated by …

[HTML][HTML] EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance

S Cao, Y Pan, J Tang, AS Terker… - Nature …, 2022 - nature.com
Obesity-related cancers are more aggressive and have shortened latency. In addition, … is
a strong cancer risk factor. Obesity has been attributed to 13 cancers, including cancers with …

Mechanisms of obesity and related pathologies: the macro‐and microcirculation of adipose tissue

JM Rutkowski, KE Davis, PE Scherer - The FEBS journal, 2009 - Wiley Online Library
… Adipose tissue macrophages serve multiple functions, … Often implicated in the adverse effects
of adipose tissues … in adipose tissue can be observed in the context of breast cancer. After …

[HTML][HTML] New insights into adipose tissue macrophages in obesity and insulin resistance

Z Cai, Y Huang, B He - Cells, 2022 - mdpi.com
… of adipose tissue macrophages (ATMs) beyond classical M1/M2 polarization in obesity and
… diverse subpopulations of ATMs in the context of obesity. Furthermore, we review the recent …