Obesity and cancer: local and systemic mechanisms

NM Iyengar, CA Hudis… - Annual review of …, 2015 - annualreviews.org
… selective enrichment of macrophage markers in breast tissue from obese women (84). As …
circulate at increased levels in obese women with breast cancer and are also associated with …

Macrophages in obesity

RM Pirzgalska, AI Domingos - Cellular Immunology, 2018 - Elsevier
obesity by discussing the genetic, cellular and functional signatures of SAMs vis-a-vis
adipose tissue macrophages … , cardiovascular disease and certain cancers), have created a …

[HTML][HTML] Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages

W Xiang, R Shi, D Zhang, X Kang, L Zhang… - … and Targeted Therapy, 2020 - nature.com
… Mechanistically, the HFD stimulated the activation of adipose tissue macrophages (ATMs) …
and obesity. Increased dietary fat consumption for a short time would not induce obesity or …

[HTML][HTML] Obesity and breast cancer: a case of inflamed adipose tissue

R Kolb, W Zhang - Cancers, 2020 - mdpi.com
obesity and breast cancer. The aim of this review is to highlight the association between obesity
and breast cancer and … is due to chronic adipose tissue inflammation. We will discuss the …

Macrophage functions in lean and obese adipose tissue

D Thomas, C Apovian - Metabolism, 2017 - Elsevier
… of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue
macrophage … Pioglitazone induced apoptosis in subcutaneous adipose tissue macrophages in …

[HTML][HTML] Obesity promotes cooperation of cancer stem-like cells and macrophages to enhance mammary tumor angiogenesis

LE Hillers-Ziemer, RQ McMahon, M Hietpas, G Paderta… - Cancers, 2020 - mdpi.com
… that obese breast cancer patients may have enhanced clinical benefit from macrophage-…
have been shown to promote angiogenesis in obese mammary tissue [32], we hypothesized …

[HTML][HTML] Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
… as metabolic syndrome, atherosclerosis, fibrosis or cancer. … We focus on macrophages
that have been studied in vivo with … In addition, while the metabolism of tissue macrophages

Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression

X Sun, P Casbas-Hernandez, C Bigelow… - Breast cancer research …, 2012 - Springer
macrophage foci in obese cancer patients (75%) is 1.25 times that among obese non-diseased
(60% among obese … genomic profile for human adipose tissue macrophage (21 genes). …

Efficient targeting of adipose tissue macrophages in obesity with polysaccharide nanocarriers

L Ma, TW Liu, MA Wallig, IT Dobrucki, LW Dobrucki… - ACS …, 2016 - ACS Publications
… disease, stroke, and cancer. The causal link between obesity and these pathologies has …
by pro-inflammatory macrophages in visceral adipose tissue. Current medications based on …

[HTML][HTML] The roles of adipose tissue macrophages in human disease

W Liang, Y Qi, H Yi, C Mao, Q Meng, H Wang… - Frontiers in …, 2022 - frontiersin.org
… , cardiovascular and cerebrovascular diseases, and breast cancer, thus posing a burden on
not … An adipose tissue macrophage is a key factor in obesity-induced insulin resistance by …