Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context

BC Christensen, EA Houseman, CJ Marsit… - PLoS …, 2009 - journals.plos.org
… underlying interindividual differences in tissue specific methylation that lead us to an
understanding of the nature of the relationships that govern these crucial tissue specific differences. …

Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation

J Zhou, RL Sears, X Xing, B Zhang, D Li… - BMC genomics, 2017 - Springer
… the tissue-specific DNA methylation patterns of rat against those of mouse and human …
three shared tissue types. We confirmed that tissue-specific differentially methylated regions …

Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer

Y Chen, CE Breeze, S Zhen, S Beck… - Epigenetics & …, 2016 - Springer
DNA methylation patterns of ten types of fetal tissue, in addition to matched normal-cancer
data for corresponding tissue … the level of aberrant cancer DNA methylation in gene promoters …

DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns

K Lokk, V Modhukur, B Rajashekar, K Märtens, R Mägi… - Genome biology, 2014 - Springer
… Our aim was to describe the general patterns of globally conserved and tissue-specific
DNA methylation with functional consequences in gene regulation. Using the high-density …

Tissue-specific differences in DNA methylation in various mammals

MA Gama-Sosa, RM Midgett, VA Slagel… - … et Biophysica Acta (BBA …, 1983 - Elsevier
… of methylation of their cytosine residues. Several similarities in the patterns of tissue-specific
DNA methylation … Compared to most other types of DNA examined, brain and thymus DNAs …

Tissue-specific DNA methylation profiles in newborns

E Herzog, J Galvez, A Roks, L Stolk, M Verbiest… - Clinical …, 2013 - Springer
tissue-specific variation in DNA methylation of two imprinted genes in easily accessible
tissuesDNA methylation analysis of these genes in umbilical cord blood. The observed between-…

Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues

S Ghosh, AJ Yates, MC Frühwald, JC Miecznikowski… - Epigenetics, 2010 - Taylor & Francis
… human somatic tissues and fewer still have studied the same sets of tissues from multiple …
to study tissue specific methylation patterns in a set of twelve human tissues collected from …

Development of tissue-specific age predictors using DNA methylation data

H Choi, S Joe, H Nam - Genes, 2019 - mdpi.com
… Thus, to address the tissue-specific characteristics of DNA methylation changes … , we
constructed tissue-specific chronological age predictors using DNA from the same tissues (Figure 1)…

Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development

P Liang, F Song, S Ghosh, E Morien, M Qin… - BMC genomics, 2011 - Springer
DNA methylation has tissue specificity, that demethylation has a prominent role in tissue
differentiation, and that DNA methylation … changes in DNA methylation during development are …

Tissuespecific dysregulation of DNA methylation in aging

RF Thompson, G Atzmon, C Gheorghe, HQ Liang… - Aging cell, 2010 - Wiley Online Library
… changes we observed are potentially valuable insights into the pathophysiology of aging, it
is the striking tissue specificity we observe that represents the most novel finding of our study. …