While TNF-α is pivotal to the pathogenesis of inflammatory osteolysis, the means by which it
recruits osteoclasts and promotes bone destruction are unknown. We find that a pure …

… The role of IGF-I as direct modulator of macrophage function has not yet been studied. To …
on macrophage activation, we sought to establish whether IGF-I may prime macrophages for …

… macrophage cytocidal function, TNF-α has … macrophage deactivator TGF-β 1 strongly
promoted TNF-α-induced osteoclast-like cell formation from immature bone marrow macrophages. …

… TNF-α contributes to macrophage-induced VSMC apoptosis. We show herein that
macrophage-derived TNF-α contributes to macrophage-… VSMCs and autocrine macrophage …

… cells may be initiated at the cell surface by the direct activation of receptor protein tyrosine
kinases (41, 42). We have found that the nonspecific tyrosine-blocking agent genistein almost …

… T lymphocytes (T8), suggesting a negative feedback by T8 cells on monocytes-macrophages.
IFN-?/ was stimulated by PHA in a reverse-dose response and this observation may be …

… This production is biphasic: within the first 8 h, this chemokine production is a direct
consequence of the activation by LPS. The release of IL-8 continues during the following 16 h. This …

… loop of macrophage activation is rather paracrine in nature and involves direct stimulation
of residual lymphoid cells to secrete IFN-γ that is then capable of activating macrophages. …

… chitins on macrophage treatment, a marked augmentation of nitric oxide production was
observed. These results are interpreted as the direct stimulation of macrophages by the …

Previously, we established that suppressing the constitutive activation of NF-κB in in vitro
matured human macrophages resulted in apoptosis initiated by a decrease of the Bcl-2 family …