The role of glial reaction and inflammation in Parkinson's disease

…, E Rousselet, S Hunot, A Hartmann… - Annals of the New …, 2003 - Wiley Online Library
… In conclusion, the data reviewed here suggest an involvement of the glial reaction and
inflammatory processes in the progression of neuronal degeneration in parkinsonian syndromes. …

Glial reactions in Parkinson's disease

PL McGeer, EG McGeer - Movement disorders: official journal …, 2008 - Wiley Online Library
… Since glia are the main generators of these processes, the possibility that PD may be caused
by glial dysfunction needs to be considered. This review concentrates on glial reactions in …

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling …

MF Sun, YL Zhu, ZL Zhou, XB Jia, YD Xu… - Brain, behavior, and …, 2018 - Elsevier
… whether brain glia are activated when fecal SCFAs increase abnormally. Thus, we
measured the interactional activities between dopaminergic neurons and brain glia, including …

Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?

EC Hirsch, S Hunot, P Damier… - Annals of neurology, 1998 - Wiley Online Library
… In this context, the glial reaction observed in neurodegenerative … that glial cells are involved
in the selective de generation of dopaminergic neurons by inducing an in flammatory reaction

Role of tumor necrosis factor-α in neuronal and glial apoptosis after spinal cord injury

YB Lee, TY Yune, SY Baik, YH Shin, S Du, H Rhim… - Experimental …, 2000 - Elsevier
We investigated the role of tumor necrosis factor (TNF)-α in the onset of neuronal and glial
, an intense immunoreactivity to TNF-α was observed in neurons and glial cells in the lesion …

Glial neuronal signaling in the central nervous system

E Hansson, L Rönnbäck - The FASEB Journal, 2003 - Wiley Online Library
… Under physiological conditions, microglia synthesize and release trophic factors; however,
as soon as there is a functional disturbance of any kind in the CNS, microglia react, proliferate…

Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells

P Zhang, X Liu, Y Zhu, S Chen, D Zhou, Y Wang - Neuroscience letters, 2013 - Elsevier
… on TNF-α in glial cells (Fig. 4A) and LPS-induced TNF-α elevation in coculture glial cells was
… However, honokiol significantly suppressed LPS-induced TNF-α elevation in coculture glial

Acute lipopolysaccharide-mediated injury in neonatal white matter glia: role of TNF-α, IL-1β, and calcium

C Sherwin, R Fern - The Journal of Immunology, 2005 - journals.aai.org
… We report that TNF-α and IL-1β directly evoke acute cell death in RON glia, with the degree
… not found to cause acute glial cell death. Combined IL-1β, IL-6, and TNF-α exposure did not …

Cascading glia reactions: a common pathomechanism and its differentiated control by cyclic nucleotide signaling

P Schubert, T Morino, H Miyazaki… - Annals of the New …, 2000 - Wiley Online Library
… Specifically, the LPS-induced release of TNF-α and IL-1β from cultivated rat microglia was
… This means that those cytokines, which tend to stimulate a cascading glial reaction, are …

TNF-α and TNF-α receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord

S Ohtori, K Takahashi, H Moriya, RR Myers - Spine, 2004 - journals.lww.com
… study was to evaluate changes in tumor necrosis factor-α (TNF-α) and TNF-α receptor 1 (p55
receptor) using double fluorescent immunohistochemistry in glial and neural cells in the …