… We used tumor necrosis factor (TNF)-α-induced apoptosis of L929 mouse fibroblast cells to
… sensitive to TNF-α. L929 HO-1 Tet+ cells were exposed to varying concentrations of TNF-α, …

… is the microsomal enzyme heme oxygenase, which catabolizes heme to biliverdin with the …
the heme oxygenase enzyme, heme oxygenase-2, and an inducible form, heme oxygenase-1 …

… have led to the appreciation that heme oxygenase 1 (HO-1) … Regulation of cyclooxygenase
by the hemeheme oxygenase … Role of human heme oxygenase-1 in attenuating TNF-alpha-…

Background: Heme-oxygenase (HO)-1 acts as an inducible defense against oxidative stress
and could play an important role in inflammation models, providing protection against …

… This study provides the first evidence to support a role for heme oxygenase (HO) as an
endogenous cytoprotective pathway in human placenta that is responsible for counteracting the …

… Heme oxygenase has three known isoforms that consist of the inducible … heme oxygenase-1
(HO-1), the constitutive isoform heme oxygenase-2, and a recently identified isoform, heme …

… Heme oxygenase (HO) is the rate-limiting enzyme … heme-HO system regulates COX enzyme
expression and activity in vascular endothelial cells in the absence and presence of TNF-α (…

… induction modulates the synthesis of tumor necrosis factor- α (TNF- α ) in hemorrhagic shock…
expression of TNF- α mRNA, as well as decreased plasma concentrations of TNF- α . These …

… We have shown that carbon monoxide (CO) generated by heme oxygenase-1 (HO-1) protects
endothelial cells (EC) from tumor necrosis α (TNF-α)-mediated apoptosis. This effect relies …

… induced HO-1 and reduced expression of tumor necrosis factor α (TNFα) messenger RNA, …
of TNFα, IL-6, and IL-8 and canceled the suppressive effects of auranofin on TNFα secretion. …