… Because IL-1β and TNF-α inhibition have the potential to alleviate IDD, … TNF-α in IDD will
benefit the development of new treatment methods for disc degeneration with IL-1β and TNF-α …

… Therefore, using TNF-α inhibitors to reverse IDD may have good efficacy. This article focuses
on the role of TNF-α in the pathogenesis of intervertebral disc degeneration and the latest …

… degeneration and low back pain. In this review, we describe the contributions of TNF-α and
IL-1β to changes seen during disc degeneration … between infection of the spine and low back …

… TNFα on whole bovine intervertebral discs in organ culture and its association with changes
characteristic of intervertebral disc degeneration (… such as TNFα contribute to disc pathology …

… injection display degenerative changes with annulus fissure, … annulus, suggesting TNF-α as
a driver in disc degeneration [16… Thus, anti-TNF-α therapy for degenerative disc disease may …

… Intervertebral disc (IVD) degeneration and IVD herniation are major causes of low back pain
… (TNF)α and their receptors in human intervertebral discs (IVDs). The percentage of disc …

… TNF-α. In this study, we detected nucleus pulposus tissue in patients with disc herniation and
intervertebral disc degeneration … kB and the expression levels of MIF, TNF-α, and IL-6 in the …

… (IL)‑17 and tumor necrosis factor (TNF)‑α in intervertebral disc degeneration (IDD) and to
identify the association between the effects of IL‑17 and TNF‑α in IDD. This may increase …

… in patients’ degenerated discs [1]; TNF-α expression in discs induces such … TNF-α has a
role as a mediator in the disc degeneration process [4]. At the onset of disc degeneration, TNF-α …

… So far, it is widely accepted that TNF-α contributes to disc degeneration by decreasing the
… TNF-α induces neuropathology and sensory nerve growth into IVD, which indicated TNF-α …