TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

J Lam, S Takeshita, JE Barker… - The Journal of …, 2000 - Am Soc Clin Investig
osteoclasts and promotes bone destruction are unknown. We find that a pure population
of murine osteoclast precursors fails to undergo osteoclastogenesis when treated with TNF-α

Regulation of TNF-induced osteoclast differentiation

Z Yao, SJ Getting, IC Locke - Cells, 2021 - mdpi.com
… of osteoclastogenesis that restrains TNFα-induced excessive … -J, TNFα effectively induced
osteoclastogenesis and bone … osteoclastogenesis and arthritic bone resorption in TNF-Tg mice …

Marrow stromal cells and osteoclast precursors differentially contribute to TNF-α-induced osteoclastogenesis in vivo

H Kitaura, MS Sands, K Aya, P Zhou… - The Journal of …, 2004 - journals.aai.org
… of direct TNF-α induction of osteoclast precursor differentiation, we do not know whether
stromal cells, as a TNF-α target, are fundamental to inflammatory osteoclastogenesis. T …

IL-1 mediates TNF-induced osteoclastogenesis

S Wei, H Kitaura, P Zhou, FP Ross… - The Journal of …, 2005 - Am Soc Clin Investig
… Having established IL-1 dependence of TNF-induced osteoclast formation in vitro, we
asked whether the same occurs in vivo. Thus, vehicle or TNF (0.75 or 1.5 μg) was injected …

TRAF2 is essential for TNFαinduced osteoclastogenesis

K Kanazawa, A Kudo - Journal of Bone and Mineral Research, 2005 - academic.oup.com
… (26) From these observations, we consider that either or both TRAF5 and TRAF6
collaborate with TRAF2 in TNFαinduced osteoclastogenesis as a consequence of TNFα‐mediated …

[HTML][HTML] TNFα and RANKL promote osteoclastogenesis by upregulating RANK via the NF‑κB pathway

G Luo, F Li, X Li, ZG Wang… - Molecular medicine …, 2018 - spandidos-publications.com
… , TNF-α likely promotes the differentiation of osteoclast … mechanisms by which TNF-α induces
osteoclastogenesis, the … NF-κB in BMMs exposed to TNF-α and RANKL individually or in …

IL-12 inhibits TNF-α induced osteoclastogenesis via a T cell-independent mechanism in vivo

M Yoshimatsu, H Kitaura, Y Fujimura, T Eguchi… - Bone, 2009 - Elsevier
… formation in spleen cell cultures in vitro, and that the IL-12-mediated inhibition of osteoclast
… IL-12 affects TNF-α-induced osteoclastogenesis and whether the effect of IL-12 on osteoclast

IL-33 inhibits TNF-α-induced osteoclastogenesis and bone resorption

…, T Noguchi, A Marahleh, Y Nara, A Pramusita… - International journal of …, 2020 - mdpi.com
… of IL-33 on TNF-α-induced osteoclastogenesis and bone resorption in vitro and in vivo. In
vivo, we focused on TNF-α-induced osteoclastogenesis. The number of TNF-α-induced TRAP-…

IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions

H Kohara, H Kitaura, Y Fujimura, M Yoshimatsu… - Immunology letters, 2011 - Elsevier
TNF-α-induced osteoclastogenesis in vivo and our data confirmed that IFN-γ inhibits TNF-α-induced
osteoclastogenesis … However, IFN-γ has contradictory actions on osteoclastogenesis

TRAF5 functions in both RANKL‐and TNFαinduced osteoclastogenesis

…, Y Azuma, H Nakano, A Kudo - Journal of Bone and …, 2003 - academic.oup.com
… RANKL‐ or TNFαinduced osteoclast differentiation, we performed a study of in vitro osteoclast
differentiation using the osteoclast … from RANK and TNF receptors in osteoclastogenesis. …