Proinflammatory cytokine (TNFα/IL‐1α) induction of human osteoclast formation

…, Y Fujikawa, I Itonaga, A Sabokbar… - The Journal of …, 2002 - Wiley Online Library
… -treated monocyte cultures was excluded by our finding that osteoclast formation
occurred in TNFα-treated cultures incubated in the presence of a neutralizing antibody to IL-1α. …

Regulation of TNF-induced osteoclast differentiation

Z Yao, SJ Getting, IC Locke - Cells, 2021 - mdpi.com
… In this review, we discuss the factors that negatively and positively regulate TNFα
induction of OC formation, and the mechanisms involved to inform the design of new anti-resorptive …

Immunological Reaction in TNFα‐Mediated Osteoclast Formation and Bone Resorption In Vitro and In Vivo

H Kitaura, K Kimura, M Ishida, H Kohara… - Journal of …, 2013 - Wiley Online Library
… treated with TNF-α in vitro, and osteoclastogenesis is inhibited by the interactions of TNF-α-…
cells concerned with osteoclast formation and immunological reactions in TNF-α-mediated …

TNF-α directly enhances osteocyte RANKL expression and promotes osteoclast formation

A Marahleh, H Kitaura, F Ohori, A Kishikawa… - Frontiers in …, 2019 - frontiersin.org
osteoclast formation after adding M-CSF and either TNF-α or … whether osteoclast formation
in co-cultures treated with TNF-α is … the formation of osteoclasts, this indicates that osteoclast

Modulation of osteoclast formation

JMW Quinn, MT Gillespie - Biochemical and biophysical research …, 2005 - Elsevier
osteoclast progenitor differentiation, osteoclast formation, osteoclast activation, and osteoclast
… action of RANKL, it has no affinity for TNFα and does not block TNFα-mediated osteoclast

Autocrine regulation of osteoclast formation and bone resorption by IL-1α and TNFα

N Tani-Ishii, A Tsunoda, T Teranaka… - Journal of dental …, 1999 - journals.sagepub.com
… In addition, we reported that rat osteoclasts expressed both IL-1 and TNF around periapical
… and TNF from mouse osteoclasts, and whether IL-1 and TNF production regulates osteoclast

Molecular mechanisms underlying osteoclast formation and activation

BR Troen - Experimental gerontology, 2003 - Elsevier
TNFα also acts to induce osteoclast formation and activation in concert with RANKL via
the TNF receptor and TRAF2 and/or TRAF6 (Komine et al., 2001, Zhang et al., 2001) and …

… -4 inhibits TNF-α-mediated osteoclast formation by inhibition of RANKL expression in TNF-α-activated stromal cells and direct inhibition of TNF-α-activated osteoclast …

T Fujii, H Kitaura, K Kimura, ZW Hakami… - Bone, 2012 - Elsevier
… 4 inhibited TNF-α-mediated osteoclast formation in … TNF-α-mediated osteoclast formation
by inhibiting expression of RANKL in TNF-α-activated stromal cells, and directly inhibited TNF-α

RANK Signaling Is Not Required for TNFα‐Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα‐Mediated …

P Li, EM Schwarz, RJ O'Keefe, L Ma… - Journal of Bone and …, 2004 - academic.oup.com
TNFα‐enhanced osteoclast formation in vivo, we used TNF‐Tg mice that overexpress a human
TNFα … ‐mediated increase in CD11b hi OCPs as well as in mature osteoclast formation at …

Osteoclast formation and differentiation: an overview

NS Soysa, A Neil, K Aoki, K Ohya - Journal of medical and dental …, 2012 - jstage.jst.go.jp
… (OC) differentiation and activation comes from the analysis of a family of biologically related
tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies that consist of receptor …