… TNF-α.37–39 Therefore, we hypothesized that PGRN deficiency would eventually facilitate
TNF-α… of FTLD associated with PGRN deficiency, we think that targeting TNF-α and/or WNT5A …

… In particular, IL-6 and TNF-α, which are measurable in human serum, were chosen here as
inflammatory markers because of their implication in the animal model of PGRN deficiency-…

… sortilin and tumor necrosis factor receptor (TNFR) are high affinity progranulin receptors, are
beginning to shed light on the mechanism(s) by which progranulin deficiency causes FTLD. …

… tumor-necrosis-factor α (TNF-α) is at the peak of the inflammatory cascade, and increased
levels of TNF … In a collagen-induced arthritis model of RA, treatment of PGRN-deficient TNF-Tg …

… that PGRN binds to tumor necrosis factor (TNF)-receptors (TNFR), interfering with the
interaction between TNFα and TNFR. They further demonstrated that mice deficient in PGRN are …

… Progranulin (PGRN), also known as granulin epithelin precursor, promotes neurite outgrowth
and cell survival, and is encoded by the GRN gene. It is a tumor necrosis factor α receptor (…

… progranulin preceded seroconversions of progranulin-… to normal progranulin,
hyperphosphorylated progranulin … PP1 induces hyperphosphorylation of progranulin in a wide …

… deficiency of PGRN led to spontaneous OA-like phenotype in ‘aged’ mice. Additionally,
PGRN-deficient … tumour necrosis factor α (TNF-α) through binding to TNF receptors, and exhibited …

… tumor necrosis factor α … We reported that PGRN inhibited TNF-α mediated activation of
NF-κB signaling in inflammatory arthritis in mice [12]. In this study, we found deficiency of PGRN …

… How PGRN deficiency-induced aberrant TNFα signaling contributes to FTD-related … deficient
mice was mediated by elevated TNFα. On the network level, we show that PGRN deficiency …