… to TNF receptors (TNFR) and have shown that PGRN-deficient … Interestingly, in TNFR1−/−
BMDMs, TNF α failed to induce … of either chemokine, suggesting that TNF-induced CXCL9 and …

… Progranulin is an antagonist of tumor necrosis factor (TNF) receptors (TNFRs) and is known
to promote inflammatory periodontal bone defect … via TNFR1 to inhibit TNF-α-sensitized NF-…

… They showed that progranulin expression was induced by TNF-α or dexamethasone and
decreased with differentiation of adipocytes [7]. Moreover, ablation of progranulin prevented …

… effect of TNFα on LSc pathology by blocking the antithrombotic effect of TNF-α on skin …
cause of neurodegenerative disease FTLD, and PGRN deficiency leads to neuronal atrophy and …

… the dichotomy of progranulin-mediated immune silencing and autoimmune mechanisms
of antigen recognition and presentation, and our results reveal a novel progranulin-dependent …

… progranulin (PGRN, encoded by GRN), a putative tumour necrosis factor receptor ligand. In
the present study, we found that progranulin … either soluble TNFα or to transmembrane TNFα, …

… 2 clinical trials for amelioration of PGRN insufficiency resultant of GRN gene mutations [68]. …
TNF-α inhibitors, Atsttrin has a unique mechanism of action targeting TNFR, but not TNF-α [19…

… in GRN haploinsufficiency, cause progranulin (PGRN)-deficient FTD characterized with …
PGRN deficiency in microglia was also found to upregulate NF-κB-TNFα signaling, resulting …

… and anti-inflammatory glycoprotein progranulin (PGRN) … of inflammatory markers in
PGRN-deficient mice (Grn −/− ) 24 h … LPS or TNFα in vitro, using iNOS and TNFα mRNA …

… TNFR1 and TNFR2, and inhibitory effect of this binding on TNF-α-induced effects [17, 18].
Dramatic effects of PGRN deficiency have been shown in vivo in collagen-induced arthritis and …