… By studying mice lacking progranulin (PGRN), the protein encoded by GRN, we … deficiency
results in impairment of autophagy, a key cellular degradation pathway. PGRN-deficient mice …

… investigated, but based on these findings, it is conceivable that PGRN might inhibit
inflammation during chronic liver disease by modulating tumor necrosis factor-α (TNF-α) signaling. …

… Progranulin impairs insulin signaling and reduces insulin-induced glucose uptake both in
vitro and in vivo whereas progranulin deficiency … the results suggest that TNFα/TNFR system is …

… progranulin gene (GRN) were first identified as an important genetic cause of frontotemporal
lobar degeneration (FTLD). Due to the highly diverse biological functions of the progranulin …

… PGRN antagonized tumor necrosis factor-α (TNF-α) through its ability … deficiency on the
activation of NF-κB signaling, immunohistochemistry was performed for phosphorylation of IκB-α, …

… progranulin levels were reduced in a subgroup of patients with autism. Progranulin insufficiency
… It was reported that progranulin bound directly to tumor necrosis factor receptors (TNFRs…

… Mutations in the progranulin gene (GRN) have recently been … mutations cause abnormal
deficiencies in the production of … Cytokines, such as tumor necrosis factor alpha (TNF-α), help …

… : progranulin, cystatin C, fructosamine, soluble cytokine receptors (interleukin-2 and -6, tumor
necrosis factor α-1 … FRAIL consists of key components of the deficit accumulation (FI) and …

… Atsttrin, a progranulin (PGRN)-derived molecule composed of three TNFR-binding domains
of PGRN, binds to TNF receptors (TNFR) and is therapeutic against inflammatory arthritis. …

… -mediated inflammation can be avoided by PGRN’s ability to block intracellular signaling
that is induced by TNF-α. TNF-α levels in serum, which is connected to the severity of the …