… The levels of PGRN significantly decreased, and the levels of MPO, IL-1β, and TNF-α were
… In addition, PGRN-deficient mice displayed exaggerated inflammation compared with wild …

… Pro-inflammatory stimuli, including tumor necrosis factor (TNF)-α and interleukin (IL)-1ß11 …
On this line, it has been shown that GRN deficient mice present an exaggerated inflammation, …

… bind the tumor necrosis factor (TNF) receptors, with competitive inhibition of TNF-α providing
… As with CTSD deficiency due to PGRN loss, GBA deficiency may be a mechanism of PGRN-…

… These studies showed that PGRN-deficient mice exhibited resistance to dietinduced …
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF…

… (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein
with unclear function. Here, we found that Grn –/– mice exhibit a global deficiency in bis(…

… PGRN‐deficient Treg cells have significantly decreased ability to suppress the proliferation
of effector T cells. PGRN deficiency … dependent, because PGRN deficiency does not alter the …

… The overexpression of the zebrafish progranulin zfPGRN-A in … -A induced a truncation defect
in CaP motor neurons that was … tumor necrosis factor, where it acts as an antagonist of TNF-…

… In this study, we aimed to evaluate serum levels of VEGF, PEDF, TNF-α, and progranulin
in patients with GC and PCL and to determine the usefulness of these markers as diagnostic …

… is much more vulnerable to PGRN deficiency. For example, the average … TNFα
expression/function. However, in human fetal microglia, we saw no evidence that PGRN acts as a …

… cortex of mouse progranulin (mPGRN)-deficient mice [… deficiency also exhibit altered
responses to lipopolysaccharide (LPS), including increased transcription of Mcp-1, Il-12p40, and Tnf…