… Tumor necrosis factor α (TNFα) is a potent proinflammatory cytokine that plays an important
role in immunity and inflammation, and in the control of cell proliferation, differentiation and …

… Signal transduction pathways are modular composites of … tumour necrosis factor (TNF)-α
triggers a signalling cascade, … network around 32 known and candidate TNF-α/NF-κB pathway …

… indicates that TNFR2 also signals to induce TRAF2 degradation. TRAF2 is a key mediator
in signal transduction of both TNFR1 and TNFR2. Thus, this novel signalling pathway has two …

… Although TNFR mediates apoptotic signal transduction, it can transduce intracellular signals
… TNF or agonistic anti-Fas antibody administration can lead to production of interleukin-8 (IL-…

… are also implicated in activating signal transduction pathways and have been shown to
phosphorylate cell surface receptors which in turn activate the MAPK signalling pathway [8]. …

… signal transduction events generating from the TNF- receptor in cardiomyocytes and defined
the hypertrophic pathways. Our results provide new insights into the role of TNF- signaling …

… role of two cytokines, namely: tumor necrosis factor α (TNF‐α), and interferon‐gamma (IFN‐γ…
CNS, their receptors, and what signaling pathways are involved in mediating their actions. …

… MM cells secrete vascular endothelial growth factor (VEGF), fibroblast growth factor (bFGF),
tumor necrosis factor α (TNF-α) and transforming growth factor β (TGF-β). BM stromal cells (…

… In conclusion, we have further defined the signal transduction pathway utilized by TNF- in …
induction of iNOS by TNF- and IFN-, the JNK/SAPK signal transduction pathway is necessary …

… We have therefore examined the mechanisms by which TNF-α is capable of inducing
apparently contradictory, survival, mitogenic, and apoptotic signals within the same cell type. The …