TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway

K Hess, A Ushmorov, J Fiedler, RE Brenner, T Wirth - Bone, 2009 - Elsevier
… that TNF-α increases BMP-2 expression in hMSCs through the NF-κB signaling pathway. …
In summary, this study is the first to show that TNF-α increases BMP-2 expression in hMSCs …

TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway

Q Zhang, F Cui, L Fang, J Hong… - Journal of molecular …, 2013 - academic.oup.com
… of TNF-α-TNFR2-Akt signaling pathway in modulating TGF-β-Smad3 signaling induced …
between these two signaling pathways. No matter the extensive understanding of TNFR1 in …

TNF and MAP kinase signalling pathways

G Sabio, RJ Davis - Seminars in immunology, 2014 - Elsevier
… by TNFα cause increased expression of TNFα by … of TNFα signalling. Here we review
mechanisms that mediate this dual role of MAP kinases in signal transduction mediated by TNFα. …

TNF-α signalling and inflammation: interactions between old acquaintances

H Zelová, J Hošek - Inflammation research, 2013 - Springer
… Ligand induced activation of TNFR1 leads to the formation of signal complexes that activate
intricate signal pathways directed in two basic ways—(a) stimulation of cell survival and …

[HTML][HTML] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory …

S Bank, PS Andersen, J Burisch, N Pedersen… - The …, 2014 - nature.com
… -like receptor (TLR) pathways, genes regulating TNF-α signaling and cytokines regulated by
… to anti-TNF therapy among patients with IBD. Genetically strong TNF-mediated inflammatory …

[HTML][HTML] Tumor necrosis factor-α (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways

…, A Heulsmann, MM Tondravi, A Mukherjee… - Journal of Biological …, 2001 - ASBMB
… their signaling pathways are considerably overlapping, we postulated that under pro-inflammatory
conditions RANKL and TNF … We found TNF, via TNF type 1 receptor (TNFr1), prompts …

Recombinant TNF-α mediated regulation of the IκB-α/NF-κB signaling pathway: evidence for the enhancement of pro-and anti-inflammatory cytokines in alveolar …

JJ Haddad - Cytokine, 2002 - Elsevier
… The novel interference of rmTNF-α in regulating IκB-α/NF-κB signaling pathway was associated
with a dual effect on extracellularly secreted cytokines. As shown in Figure 5A, rmTNF-α (…

[HTML][HTML] Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor α gene expression in T lymphocytes

A Hoffmeyer, A Grosse-Wilde, E Flory, B Neufeld… - Journal of Biological …, 1999 - ASBMB
signaling pathways that regulate TNF expression in T cells. Here we show that extracellular
signal… kinase (MAPK) pathways control the transcription and synthesis of TNF-α in A3.01 T …

[HTML][HTML] Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-α signaling pathways

W Jeong, TS Chang, ES Boja, HM Fales… - Journal of Biological …, 2004 - ASBMB
… Here we studied the possible roles of TRP14 in TNF-α signaling in comparison with
those of … in enhancement of TNF-α-induced activation of caspases and NF-κB. The TNF-α-induced …

TNF-α and obesity

T Tzanavari, P Giannogonas, KP Karalis - TNF Pathophysiology, 2010 - karger.com
… adipocytes, TNF-α autoamplification occurred via the protein kinase C signaling pathway and
… When injected with TNF-α, C57BL/6J mice upregulated TNF-α mRNA levels in adipocytes …