Connecting TNF-α signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by …

R Medeiros, RDS Prediger, GF Passos… - Journal of …, 2007 - Soc Neuroscience
tumor necrosis factor-α (TNF-α)-related signaling pathways and inducible nitric oxide synthase
(iNOS) expression in a mouse model of … of Aβ 1–40 in mice resulted in marked deficits of …

TNFα increases inflammatory factor expression in synovial fibroblasts through the toll‑like receptor‑3‑mediated ERK/AKT signaling pathway in a mouse model of …

FY Yu, CQ Xie, CL Jiang, JT Sun… - Molecular medicine …, 2018 - spandidos-publications.com
tumor necrosis factor (TNF)‑α is associated with osteoarthritis activity and pathology. The
possible mechanisms of the TNFα‑mediated signaling pathway … of TNFα in a mouse model of …

The TNF-α transgenic mouse model of inflammatory arthritis

P Li, EM Schwarz - Springer seminars in immunopathology, 2003 - Springer
… Collectively, these studies strongly suggest that targeting the RANKL/RANK signaling
pathway (eg, administration of OPG) may be an effective therapeutic treatment of inflammatory …

Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation

W Li, Y Dong, Y Tu, Z Lin - International immunopharmacology, 2006 - Elsevier
Murine models of lupus, including the BXSB mouse, have been proved invaluable in the
analyses of the pathogenesis of SLE. BXSB mice spontaneously develop a human lupus-like …

Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis

X Gao, M Guo, Z Zhang, T Wang, Y Cao, N Zhang - Inflammation, 2015 - Springer
… NO, TNF-α, IL-1β, and IL-6 proinflammatory cytokines by inhibiting the activation of the NF-κB
and MAPKs signaling pathways, … Here, our study was performed with the mouse model of …

TNF-α blockage in a mouse model of SCI: evidence for improved outcome

T Genovese, E Mazzon, C Crisafulli, R Di Paola… - Shock, 2008 - journals.lww.com
… (mice with a targeted deletion of the TNF-α R1 gene TNF-α R1KO) or pharmacological (TNF-α
R1WT mice treated with infliximab) inhibition of TNF-α … inhibition of TNF-α decrease the …

Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS

P Veglianese, DL Coco, MB Cutrona, R Magnoni… - Molecular and Cellular …, 2006 - Elsevier
… that delineates a specific intracellular signaling pathway, which may be involved in the
mechanisms promoting the degeneration of motor neurons in the SOD1G93A mice. First, we …

MPTP activates ASK1–p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model

A Ray, N Sehgal, S Karunakaran, G Rangarajan… - Free Radical Biology …, 2015 - Elsevier
… We investigated upstream activators of ASK1 using an MPTP mouse model of parkinsonism
and assessed the temporal cascade of death signaling in ventral midbrain (VMB) and …

Gsdma3 is a new factor needed for TNF-α-mediated apoptosis signal pathway in mouse skin keratinocytes

M Lei, X Bai, T Yang, X Lai, W Qiu, L Yang… - Histochemistry and cell …, 2012 - Springer
… A variety of signaling pathways are involved in skin keratinocyte apoptosis. … TNF-α-induced
apoptosis pathway, in this study, Gsdma3 expression in mouse skin keratinocytes after TNF-α

The role of tumor necrosis factor signaling pathways in the response of murine brain to irradiation

JL Daigle, JH Hong, CS Chiang, WH McBride - Cancer research, 2001 - AACR
TNF-α signaling in the response to brain irradiation using TNFRp55- or TNFRp75-deficient
and control mice. … To study the potential role of TNF-α signaling in the proliferative response, …