… for surfactant function ( 1-3) for review. Surfactant protein A, the most abundant surfactant
protein… SP-A binds and aggregates surfactant phospholipids in the alveolus (4) and confers the …

… Surfactant protein A protects growing cells and reduces TNF-… In addition to its effect on
surfactant lipids, surfactant protein (SP)… partially by affecting tumor necrosis factor (TNF)-ok activity. …

… In the present study, TNF-α markedly inhibited surfactant protein C gene expression in
association with stimulation of ICAM-1 mRNA, an adhesion molecule that modulates the binding …

… Tumor necrosis factor-a decreases surfactant protein B … Thus elevated TNF-cx is associated
with diseases complicated … hypothesis that TNF-a alters production of surfactant components …

… surfactant plays a variety of roles related to the regulation of immune function in the lung. Of
particular interest in this regard is surfactant protein … secretion of tumor necrosis factor-a (TNF-…

… Surfactant protein (SP) D shares target cells with the proinflammatory cytokine TNF-α, an
important … We sought to study the mechanisms by which TNF-α and SP-D can affect cellular …

… TNF-α inhibition of the surfactant proteins in NCI-H441 cells. Pentoxifylline (PTX), which inhibits
TNF-α … By EMSA, TPA and TNF-α increased nuclear NF-κB binding activity in temporally …

… most abundant hydrophilic protein present in pulmonary surfactant and plays an … surfactant
proteins (SP-A, SP-B, and SP-C), transcription factors (c-fos and c-Jun), and surfactant protein …

… Lipopolysaccharide-induced tumor necrosis factor α production by human monocytes
involves the Raf-1/MEK1-MEK2/ERK1-ERK2 pathway. Infect Immun 67: 3824-3829, 1999. …

… In conclusion, the major surfactant protein SP-A was found to inhibit the LPS-induced TNFα
response of both interstitial and alveolar human Mφ, as well as the IL-1 response in iMφ. The …