… TNF-α has been described to enhance IL-12 production in the context … TNF-α on IL-12
production by DCs. In the presence of TNF-α, PGE2 dose dependently stimulated high level IL-12 …

… of IL-18 on TNF-α-induced osteoclastogenesis was investigated in vivo. In addition, the
synergistic effect of IL-12 and IL-18 was assessed in vivo and the issue of whether the effect of IL-…

… synergy in nitric oxide, TNF-α and interleukin (IL-12 and IL-6) production. We did not see in
human PBMC appreciable induction of TNF-α, IFN-γ, and IL… demonstrated a synergy between …

… a unique synergy between IL-12 and TNF-α that was … of IL-12 and TNF-α at the site of a
tumor results in a potent systemic anti-tumor response. In this report, we show that the synergistic …

… to understand the mechanism for synergy between IL-12 and TNF-α in up-regulating IFN-γ …
for selection, IL-12 and TNF-α synergize to up-regulate not only IFN-γ, but also the IL-12Rβ2 …

… In conclusion our data point towards a synergy between IL-12 and IL-15 in inducing an
IFN-γ-independent immune response, where other cytokines may compensate for the lack of IFN-…

… the expression of tumor necrosis factor α (TNF-α), IL-12, and … TNF-α and IL-12 were
quantified in the supernatant of organ … Both TNF-α and IL-12 levels were significantly reduced …

It has recently been reported that TNF-α has the ability to accelerate osteoclastogenesis.
We previously reported that the proinflammatory cytokine IL-12 induced apoptosis in TNF-α-…

… (21, 23, 29), and their synergistic actions have been attributed to enhanced IFN-γ … act in
synergy to inhibit osteoclast formation. Importantly, the synergistic action of IL-12 and IL-18 to …

… TNFα and IFNγ on B16F10 melanoma cells in vitro (Fig. 3B). According to earlier reports,
synergistic cytostatic/cytotoxic effects of IFNγ and TNFα … synergistic interactions between TNFα …