… Thus, these reagents still allow residual TNF receptor activation via LTα (TNFR1) and …
of the TNF-blocking antibodies in rheumatic diseases and/or other TNFR1-driven diseases is …

… , or agonize the anti-inflammatory receptors, are being considered for the treatment of … of
the TNF superfamily that could be relevant for the pathogenesis of rheumatic disease, including …

… disease activity. Conclusion. Biologically active soluble TNF-R are up-regulated in patients
with rheumatic disease … serum levels of TNF-R may be useful for monitoring of disease, and …

… Cytokines bind to specific receptors on target cells and stimulate signal transduction … in
rheumatic diseases. Abnormalities in cytokine production are not the cause of these diseases, but …

… rheumatic diseases has been reported. We review novel insights on the role of TLRs in several
inflammatory joint diseases, including rheumatoid … TLR signalling in rheumatic diseases. …

… either by antibodies or soluble receptors could constitute a promising therapeutic … -1 or TNF
and their respective soluble receptors in biological fluids may dictate the severity of disease, …

… -bound TNF-α and can inhibit the activation of TNF receptors … that TNF plays a role in these
inflammatory rheumatic diseases… anti-TNF-α therapy in the treatment of these diseases will be …

… interact with either of two distinct receptors, TNF receptor 1 (TNFR1, p55) … TNF in the
pathogenesis of chronic inflammatory diseases such as RA, PsA, AS, inflammatory bowel diseases, …

… disorders and provided the first clue that the inflammasome has a potential role in rheumatic
diseases [9]… and management of these disorders and has implications for future therapies in …

… , the different effects of oestrogens on their different receptors or on different target cells,
the … However, as supported by the higher prevalence of rheumatic autoimmune diseases in …