… induced by TNF-α plus cycloheximide (Figure 3A). In contrast, knockdown of caspase-8 rescued
cell death in … was observed with cycloheximide, cell death induced by TNF-α plus c-FLIP …

… and caspase-8. In the case of ligation of TNFR1, another adapter, TNF receptor type 1-associated
DEATH … induced by TNF, but not for that induced by other death receptor ligands. Other …

… To test this hypothesis, we intravenously administered TNF-α to Casp8 ΔIEC mice using a
dose that is not lethal to normal mice. Whereas all control mice were still alive after 5 h, Casp8 …

… the balance of life and death is still unknown. We report here that … death domain kinase
RIP, a key component of the TNF signaling complex, was cleaved by Caspase-8 in TNF-induced …

… Recently, however, XIAP has also been shown to critically regulate both cell death and
innate immune responses following TNF and TLR ligation (discussed later in this review). …

… Here, we report that caspase-8–dependent GSDMD cleavage confers susceptibility to
tumor necrosis factor (TNF)–induced lethality independently of caspase-1 and that GSDMD …

… the involvement of caspase-8 in cell death and inflammation … and in the relationship between
different forms of cell death. … , caspase-8 inhibitors trigger necroptosis during TNF or LPS …

… -associated cell death driven by catalytically inactive caspase-8 was recently … γ/TNF-α-induced
killing, we found that the scaffold function of caspase-8 facilitated activation of lethal JAK1/…

… TNF stimulation from one of proliferation to one of cell death. The sequential steps of the
TNF-induced death … Binding of TNF to TNF receptor 1 (TNFR1) results in receptor trimerization …

… role of Tnf-α in TLR-induced epithelial cell death. Indeed, we detected significant levels of
Tnf-α … Thus, our data suggest that poly(I:C)-induced cell death in caspase-8-deficient epithelial …